Test 3 Flashcards
(164 cards)
What does CHG stand for?
Chlorhexidine Gulconate
What is CHG?
Chlorhexidine Gluconate is a bis-biguranide which are cationic, broad-spectrum antimicrobials effective for both gram-positive and gram-negative bacteria.
How is CHG used?
Predominantly used in prescription oral rinses, irrigation solutions, and controlled-realase products
When should CHG be prescribed?
To facillitate healing 4-6 weeks after perio surgery and in the DH clinic to aid in plaque reduction and gingivitis (gingival bleeding) with DD3 and DD4 clients. (Reeval visits)
How does CHG work?
Attaches to salivary proteins and prevents pellicle formation. Attaches to the bacterial cell wall and distrupts its ability to colonize
What is the dosage of CHG?
20mL dosage for 60 seconds twice daily
What are the disadvantages of CHG?
Brown staining
Increased calculus deposition
May cause allergic reaction
30 minutes between CHG and brushing to avoid interacion with the detergent (sodium lauryl sulfate) which deactivates the CHG
What are the contraindications for CHG?
Do not use for long periods of time
Anterior restorations
Allergies or hypersensitivites to chlorhexidine gluoconate, chlorhexidine compounds or other ingredients
What schedule category does chlorhexidine fall under?
Schedule 1
What is an example of a phenolic compound?
Listerine
What is the main reason that the level of reduction in plaque and gingivitis seen with chlorhexidine is greater than that noted for phenolic mouth rinses?
Superior substantivity of chlorhexidine - its binding lasts longer
Why did the authors exclude patients with systemic disease from the study?
To eliminate potential confounding factors that could interefere with the results
What is the evidence that proves professionally applied oral irrigation has limited clinic value?
Not retained in adequate concentrations for sufficient duration to have significant effects on periodontal disease
Some active ingredients such as chlorhexidine gluconate are deactivated by blood and proteins
Gingival crevicular fluid is replaced about every 90 seconds reducing the concentration of an antimicrobial agent that reaches the subgingival organisms
How should antimicrobials be used in the treatment of periodontal diseases?
To supplement mechanical debridement
What is the difference between local and systemic delivery methods?
Local - the antimicrobial agent is applied directly to the oral cavity or to a specific location within it
Systemic - ingested by the patient and delivered via the blood stream
What agent kills or prevents propagation of plaque microorganisms?
Antiseptic agents
What agent inhibits or kills specific or groups of bacteria, or modulates host inflammatory response?
Antibiotics
What agent alters structure and/or metabolic activity of bacteria?
Modifying agents
What agent interferes with the ability of bacteria to attach to acquired pellicles?
Anti-adhesives
What is the goal of professionally applied products?
Aimed at reducing pathogenic bacteria in diseased sites that have resisted healing
What are some pros of professionally applied products?
Controlled-release drug delivery
Does not require patient compliance
Non-invasive
Able to reach the base of the periodontal pockets
What are some cons of professionally applied products?
Active ingredients may not be retained in adequate concentrations for sufficient periods of time or may become deactivated by blood products
What is the main ingredient of Antridox?
Doxycycline hyclate 10%
How is Antridox delivered?
Gel polymer that flows to the pocket base and solidifies on contact with gingival crevicular fluid