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Pathogenic Bacteriology > Test 2 proteins > Flashcards

Test 2 proteins Flashcards

1
Q

Vmp

A

Variable major protein on borrelia that can change, causing relapsing fever.

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2
Q

OspA-F

A

Borrelia Outermembrane surface protein, helps to evade host immune response

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3
Q

CRASP/ERP

A

Borrelia complement binding lipoproteins, prevent complement activation

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4
Q

DbpA,B

A

Borrelia decorin binding protein, messes with cell collagen and cell growth

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5
Q

SodA, C

A

Superoxide dismutase in Mycobacterium tuberculosis

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6
Q

Kat-G

A

Peroxidase in Mycobacterium tuberculosis

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7
Q

Man-LAM

A

Major anti-inflammatory cell wall component in Mycobacterium tuberculosis. Prevents acidification of phagosomes, resists ROS, and inhibits T cell activation.

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8
Q

Icl

A

Isocitrate lyase in Mycobacterium tuberculosis, allows for growth on fatty acids and acetate as sole carbon source.

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9
Q

FadD

A

acyl-CoA synthase in Mycobacterium tuberculosis, facilitates first step in fatty acid breakdown, 36 orthologs in Mtb.

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10
Q

SigE

A

Mtb stress factor, hi temp, ROS

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11
Q

SigH

A

Mtb stress factor, hi temp, SDS

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12
Q

PhoP

A

Mtb protein, regulates 44 genes, half fatty acid metabolism, half affect ESAT-6, CFP 10

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13
Q

Sca0,1,2,5

A

Rickettsia Surface Cell Antigens, bind to host cell receptors to mediate attachment.

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14
Q

BoNT

A

C. botulinum toxin, targets PNS and blocks muscle stimulation.

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15
Q

TeNT

A

C. tetani toxin, targets CNS and blocks muscle relaxation.

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16
Q

TcdA, B

A

C. difficile toxin, glucosylates hosts GTPases preventing actin polymerization.

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17
Q

TcdR

A

C. difficile positive regulator of TcdA/B and itself.

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18
Q

SigD

A

C. difficile positive regulator of TcdR

19
Q

TcdC, CodY

A

C. difficile negative regulator of TcdR

20
Q

CcpA

A

C. difficile negative regulator of TcdR, A, B

21
Q

Tarp

A

Chlamydia protein that induces actin polymerization, injected via T3SS

22
Q

IncA

A

Chlamydia protein involved in inclusion fusion.

23
Q

CPAF

A

Chlamydia protein, secreted protease, cleaves host proteins.

24
Q

CopN

A

Chlamydia protein, similar to YopN in Yersinia

25
Q

PlcH, PlcN

A

Pseudomonas hemolytic phospholipases

26
Q

LasA, B

A

Pseudomonas protein that degrades host elastin, collagen, immunoglobins, complement components

27
Q

Pyochelin

A

Pseudomonas blue pigment that forms OH-, causing oxidative damage to eukaryotic cells

28
Q

Pyocyanin

A

Pseudomonas green pigment that catalyses formation of 02- and H202 from 02. Causes oxidative damage to eukaryotic cells.

29
Q

Exotoxin A

A

Pseudomonas toxin, inhibits eukaryotic translation.

30
Q

ExoS, T

A

Pseudomonas effectors that have a GAP domain (inactivates actin polymerization) and ADP-ribosyltransferase domain (prevents wound healing.)

31
Q

ExoY

A

Pseudomonas effector with adenylate cyclase activity (ATP —-> cAMP)

32
Q

ExoU

A

Pseudomonas effector with lipase activity.

33
Q

YopE

A

Yersinia effector that inactivates Rho and its ability to rearrange the actin skeleton.

34
Q

YopT

A

Yersinia effector cysteine protease, cleaves Rho GTPase from the cell membrane, preventing it from working.

35
Q

YopO

A

Yersinia effector serine/threonine kinase, binds Rac and Rho interfering with their activity, also can act directly on actin to prevent polymerization.

36
Q

YopH

A

Yersinia effector tyrosine phosphatase, inhibits oxidative burst, inhibits bacterial uptake, inhibits degranulation.

37
Q

YopJ

A

Yersinia effector acetyltransferase, inhibits NF-kB by acetylating IKKB.

38
Q

LcrV

A

Yersinia protein, point of the T3SS, induces IL-10

39
Q

Pla

A

Yersinia outter membrane serine protease, cleaves C3 and activates plasminogen.

40
Q

F1 Capsular Antigen

A

Yersinia pestis antiphagocytic antigen. Confers protection in animal models.

41
Q

Yersiniabactin

A

Yersinia siderophore, without this yersinia becomes attenuated.

42
Q

pXO1

A

Bacillus anthracis plasmid that encodes for anthrax toxin. Sterne vaccine.

43
Q

pX02

A

Bacillus anthracis plasmid that encodes for poly-D-glutamic acid capsule. Pasteur vaccine.

Pathogenic Bacteriology (2 decks)

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