Test 2 proteins

Question 1

Vmp

Answer 1

Variable major protein on borrelia that can change, causing relapsing fever.

Question 2

OspA-F

Answer 2

Borrelia Outermembrane surface protein, helps to evade host immune response

Question 3

CRASP/ERP

Answer 3

Borrelia complement binding lipoproteins, prevent complement activation

Question 4

DbpA,B

Answer 4

Borrelia decorin binding protein, messes with cell collagen and cell growth

Question 5

SodA, C

Answer 5

Superoxide dismutase in Mycobacterium tuberculosis

Question 6

Kat-G

Answer 6

Peroxidase in Mycobacterium tuberculosis

Question 7

Man-LAM

Answer 7

Major anti-inflammatory cell wall component in Mycobacterium tuberculosis. Prevents acidification of phagosomes, resists ROS, and inhibits T cell activation.

Question 8

Icl

Answer 8

Isocitrate lyase in Mycobacterium tuberculosis, allows for growth on fatty acids and acetate as sole carbon source.

Question 9

FadD

Answer 9

acyl-CoA synthase in Mycobacterium tuberculosis, facilitates first step in fatty acid breakdown, 36 orthologs in Mtb.

Question 10

SigE

Answer 10

Mtb stress factor, hi temp, ROS

Question 11

SigH

Answer 11

Mtb stress factor, hi temp, SDS

Question 12

PhoP

Answer 12

Mtb protein, regulates 44 genes, half fatty acid metabolism, half affect ESAT-6, CFP 10

Question 13

Sca0,1,2,5

Answer 13

Rickettsia Surface Cell Antigens, bind to host cell receptors to mediate attachment.

Question 14

BoNT

Answer 14

C. botulinum toxin, targets PNS and blocks muscle stimulation.

Question 15

TeNT

Answer 15

C. tetani toxin, targets CNS and blocks muscle relaxation.

Question 16

TcdA, B

Answer 16

C. difficile toxin, glucosylates hosts GTPases preventing actin polymerization.

Question 17

TcdR

Answer 17

C. difficile positive regulator of TcdA/B and itself.

Question 18

SigD

Answer 18

C. difficile positive regulator of TcdR

Question 19

TcdC, CodY

Answer 19

C. difficile negative regulator of TcdR

Question 20

CcpA

Answer 20

C. difficile negative regulator of TcdR, A, B

Question 21

Tarp

Answer 21

Chlamydia protein that induces actin polymerization, injected via T3SS

Question 22

IncA

Answer 22

Chlamydia protein involved in inclusion fusion.

Question 23

CPAF

Answer 23

Chlamydia protein, secreted protease, cleaves host proteins.

Question 24

CopN

Answer 24

Chlamydia protein, similar to YopN in Yersinia

Question 25

PlcH, PlcN

Answer 25

Pseudomonas hemolytic phospholipases

Question 26

LasA, B

Answer 26

Pseudomonas protein that degrades host elastin, collagen, immunoglobins, complement components

Question 27

Pyochelin

Answer 27

Pseudomonas blue pigment that forms OH-, causing oxidative damage to eukaryotic cells

Question 28

Pyocyanin

Answer 28

Pseudomonas green pigment that catalyses formation of 02- and H202 from 02. Causes oxidative damage to eukaryotic cells.

Question 29

Exotoxin A

Answer 29

Pseudomonas toxin, inhibits eukaryotic translation.

Question 30

ExoS, T

Answer 30

Pseudomonas effectors that have a GAP domain (inactivates actin polymerization) and ADP-ribosyltransferase domain (prevents wound healing.)

Question 31

ExoY

Answer 31

Pseudomonas effector with adenylate cyclase activity (ATP ----> cAMP)

Question 32

ExoU

Answer 32

Pseudomonas effector with lipase activity.

Question 33

YopE

Answer 33

Yersinia effector that inactivates Rho and its ability to rearrange the actin skeleton.

Question 34

YopT

Answer 34

Yersinia effector cysteine protease, cleaves Rho GTPase from the cell membrane, preventing it from working.

Question 35

YopO

Answer 35

Yersinia effector serine/threonine kinase, binds Rac and Rho interfering with their activity, also can act directly on actin to prevent polymerization.

Question 36

YopH

Answer 36

Yersinia effector tyrosine phosphatase, inhibits oxidative burst, inhibits bacterial uptake, inhibits degranulation.

Question 37

YopJ

Answer 37

Yersinia effector acetyltransferase, inhibits NF-kB by acetylating IKKB.

Question 38

LcrV

Answer 38

Yersinia protein, point of the T3SS, induces IL-10

Question 39

Pla

Answer 39

Yersinia outter membrane serine protease, cleaves C3 and activates plasminogen.

Question 40

F1 Capsular Antigen

Answer 40

Yersinia pestis antiphagocytic antigen. Confers protection in animal models.

Question 41

Yersiniabactin

Answer 41

Yersinia siderophore, without this yersinia becomes attenuated.

Question 42

pXO1

Answer 42

Bacillus anthracis plasmid that encodes for anthrax toxin. Sterne vaccine.

Question 43

pX02

Answer 43

Bacillus anthracis plasmid that encodes for poly-D-glutamic acid capsule. Pasteur vaccine.