Final

Question 1

Two major virulence factors of ETEC

Answer 1

enterotoxins and colonization factor antigens

Question 2

LT

Answer 2

Labile Toxin in ETEC GM1 ganglioside receptor ADP-Ribosylates G protein to make a bunch of cAMP

Question 3

ST

Answer 3

Heat Stable Toxin in ETEC activates Guanylate cyclase converts GTP to cGMP

Question 4

Colonization factors

Answer 4

Fibrial antigens in ETEC, confer host range, vaccine candidate,

Question 5

BFP

Answer 5

EPEC bundle forming pilus. Encoded by 14 plasmid borne genes. Helps form bacterial “bundles”

Question 6

LEE

Answer 6

locus of enterocyte effacement in EPEC encodes Tir and intimin

Question 7

EspF

Answer 7

EPEC T3SS effector. Disrupts tight junctions.

Question 8

EspB

Answer 8

EPEC T3SS effector. Inhibits A and B catenin and allows actin polymerization.

Question 9

Map

Answer 9

EPEC T3SS effector. Damages Mitochondria.

Question 10

Per

Answer 10

EPEC gene regulator. Regulates BFP and some LEE locus genes. Made up of PerA, PerB and PerC.

Question 11

SLT

Answer 11

Shiga-like toxin in EHEC.

Question 12

Pap fimbriae

Answer 12

UPEC fimbriae that attach to gal gal residue and prevent expulsion from UT. Helps form IBCs

Question 13

RTX Toxin

Answer 13

UPEC pore-forming toxin. Exists as HlyA until it is acylated.

Question 14

hlyC

Answer 14

UPEC. acylates HlyA.

Question 15

hlyB

Answer 15

UPEC. Transports HlyA across inner membrane.

Question 16

hlyD

Answer 16

UPEC. Transports HlyA across outer membrane.

Question 17

Sat/Vat

Answer 17

UPEC. Vacuolating toxin.

Question 18

CNT

Answer 18

UPEC. Cytotoxin necrotizing factor. Causes actin rearrangements and membrane ruffling.

Question 19

SopE

Answer 19

Salmonella. Recruits Rac and allows actin polymerization.

Question 20

SipA

Answer 20

Salmonella. Recruits actin.

Question 21

PhoP/PhoQ

Answer 21

Salmonella. Down regulate SPI1 and activate SPI2.

Question 22

hilA

Answer 22

Salmonella. SPI1 regulator that responds to low O2, high osmolarity, and ph7.

Question 23

VirB, VirF

Answer 23

Shigella. Regulators of virulence genes. Respond to osmolarity, temp, etc.

Question 24

IpaC

Answer 24

Shigella. Required for internalization.

Question 25

Ics

Answer 25

Shigella. Proteins that mediate actin polymerization for movement within the host cell.

Question 26

IpaA

Answer 26

Shigella. Binds to vinculin to form a pedestal like structure.

Question 27

IpaB

Answer 27

Shigella. Contact lysin, releases shigella from the vacuole.

Question 28

IcsA

Answer 28

Shigella. Outter membrane protein that localizes to one pole and binds vinculin for actin polymerization and movement within host cell.

Question 29

OspE

Answer 29

Shigella. Prevents shedding of infected endothelial cells.

Question 30

ToxRS/ToxPH

Answer 30

V cholerae. Affects ToxT expression.

Question 31

ToxT

Answer 31

V cholerae. Affects ctx and tcp expression.