Test 2 Human Biology Flashcards

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0
Q

Stages of digestion?

A

Ingestion: taking in food- put in mouth and chewed. swallowing takes it down the oesophagus and into stomach. Food is propelled through alimentary canal by peristalsis (rhythmic contractions of gut wall). Mechanical breakdown: breaking up food into smaller pieces- chewing or churning action of stomach. Digestion: chemical breakdown of complex food molecules (carbohydrates, proteins, fats) into simpler ones. Mainly in small intestine, duodenum, but is started in stomach. Absorption: the passage into bloodstream of simple food molecules such as peptides, sugars, fatty acids, vitamins, minerals, water. takes place mainly in the ileum of the small intestine Egestion: the elimination of undigested food materials from the body.

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1
Q

Stages of digestion?

A

Ingestion: taking in food- put in mouth and chewed. swallowing takes it down the oesophagus and into stomach. Food is propelled through alimentary canal by peristalsis (rhythmic contractions of gut wall). Mechanical breakdown: breaking up food into smaller pieces- chewing or churning action of stomach. Digestion: chemical breakdown of complex food molecules (carbohydrates, proteins, fats) into simpler ones. Mainly in small intestine but is started in stomach. Absorption: the passage into bloodstream of simple food molecules such as peptides, sugars, fatty acids, vitamins, minerals, water. takes place mainly in the ileum of the small intestine. Egestion: the elimination of undigested food materials from the body.

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2
Q

Humans cannot make our own food, so we are…

A

Heterotrophs

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3
Q

DS role of mouth?

A

Ingestion: food enters DS through mouth and is crushed&ground by teeth. Muscular tongue moves food in mouth

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4
Q

DS role of salivary glands?

A

Already during ingestion, saliva lubricates food and contains enzymes that kickstart digestion

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5
Q

Components of saliva?

A

Digestive enzymes: salivary amylase -> starches Mineral salts Water Mucin- glycoprotein lubricant Lysozyme- bactericide

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6
Q

DS role of oesophagus?

A

Thick-walled muscular tube that connects pharynx (throat) with stomach

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7
Q

Throat fancy word?

A

Pharynx

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8
Q

DS function of liver?

A

Processes absorbed nutrients, detoxifies harmful substances and produces bile

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9
Q

Bile?

A

Green and bitter substance that helps digestion in small intestine. Produced by gall bladder in liver. Contains water, bile salts, bile pigments, cholesterol. Bile pigments break down old red blood cells, hence the green colour. Bile salts are organic molecules with a permanent charge. As a salt it is hydrophilic. They surround globular lipids and provide space for lipase enzyme to work in the spaces. Functions of bile salt: 1. Solubilise 2. Neutralise chyme from stomach 3. Stimulate peristalsis 4. Allow excretion of cholesterol, lipids, bile pigments

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10
Q

DS function of stomach?

A

Churns, digests, and stores food.

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12
Q

What happens in the stomach?

A

Low pH environment ~2 - most bacteria cannot survive Activates some digestive enzymes: PEPSIN! Produced when pepsinogen is secreted by stomach lining and is activated by HCl in stomach. Pepsin is an endopeptidase enzyme- breaks peptide bonds into proteins, making smaller chains. Then an exopeptidase enzyme breaks p-bonds on terminal ends, leaving monomers that can be absorbed. Lipase is a stomach enzyme that breaks down fats into glycerol and fatty acids. Rennin is a milk digestion enzyme. Its inactive form is prorenin and is also activates due to acid (H+) environment, causes unfolding in protein (permanent structural change). The soluble proteins in milk are caseinogena

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13
Q

control of digestion?

A

we do not eat food continuously, it is important that digestive enzymes are produced only after we have eaten. otherwise it’d be a potential danger that you’d digest yourself. 1. nervous phase- sight, smell, taste of food initiates a nerve reflex in which impulses from the brain trigger gastric glands to release their secretions 2. gastric phase (hormonal)- food in stomach stimulates the lining to secrete the hormone gastrin. it increases gastric juice secretion through direct action on gastric glands. 3. intestinal phase (hormonal)- the duodenal lining, stimulated by partially digested food, produces a second hormone, enteric gastrin. pressure sensors and chemical sensors in stomach detect stretching and the presence of chyme. the resulting nerve impulses together with the action of gastrin direct the stomach to start emptying its contents into the duodenum.

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14
Q

explain how the structure of the ileum relates to its function of absorbing the products of digestion.

A

large surface area: a lot of intestine is in contact with a lot of digested food molecules. these are absorbed by diffusion or active transport, so more membrane = more pores and carrier proteins. long intestine = more surface area. good blood supply: organ adapted for exchange of materials, so there’s a way of maintaining the diffusion gradient so that there’s always more food on one side than the other. thus ensuring that absorption is continuous and fast. as soon as food molecules enter the bloodstream, they are replaced with blood containing fewer of these molecules. thin walls: thin membrane = quick diffusion.

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15
Q

DS egestion in detail?

A

after food has been through the large intestine. the large intestine has 4 parts: caecum, colon, rectum and anus. the large int. absorbs water, is the site of manufacture of certain vitamins, forms and expels undigested food residue as faeces. saliva, gastric + pancreatic juice is reabsorbed.

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16
Q

alt. name of DS?

A

alimentary canal

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17
Q

types of tissue?

A

epithelial: thin protecting sheet e.g. skin connective: tough fibrous, keeps things in place e.g. ligaments muscular: a. skeleton- attached to skeleton that we have voluntary control over b. smooth involuntary e.g. digestive muscles c. cardic nervous: brain + spinal cord

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18
Q

basic job of NS?

A

detects and interprets changes in body’s environment (stimuli)

19
Q

two general parts of NS?

A

central NS: brain + spinal cord peripheral NS: somatic NS + autonomic NS

20
Q

reflex arc?

A

e.g. when you burn your hand, that stimulus isn’t processed in the brain. you need to get your hand off the stove as quick as possible, so to save time as to minimise any damage, it’s processed by the spinal cord. the reflex arc bypasses the brain, the brain simply notices that it has happened.

21
Q

Parts of the brain + functions?

A

Cerebrum: largest part of the brain. divided into 4 paired lobes- frontal, temporal, occipital, pariteal. folds in cerebrum known as grooves. deep grooves are called fissures and shallow grooves as sulci.

lognitudal fissure divides brain in half- left and right hemispheres

pituitary gland: hormone relasing-gland under the control of the hypothalamus

cerebral cortex: where thinking happens.

hypothalamus: regulation of bodily processes. coordinating system between nervous and endocrine system.
thalamus: receives sensory information and relays it to the cortex
cerebellum: takes care of things you don’t think about, controls balance and coordinates movement

22
Q

matter of the brain?

A

grey matter: cell bodies + synapses

white matter: axons only

23
Q

mentally draw a diagram of a generalised reflex arc.

A
24
Q

Parts of perihperal NS?

A

Somatic nervous system:

Runs voluntary control of movement. Receives and processes info from receptors in skin, voluntary muscles, tendons, joints, eyes, tongue, nose and ears, giving an organism the sensations of touch, pain, heat, cold, balance, sight, taste, smell and sound.

Autonomic nervous system:

Below the level of consciousness, carries out tasks you do not think about. ‘Housekeeping’ system: heart rate, breathing, digestion, blood flow. The system is entirely motor, only efferent nerves.

25
Q

Autonomic NS?

A

Sympathetic vs Parasympathetic. Antagonistically acts w/ opposing effects.

Sympathetic:

Stimulatory effect, prepares body for action. ‘Fight or flight’ reactions. Increase in heart rate, faster breathing, increase in blood pressure and sugar level.

Parasympathetic:

once the emergency is over, parasympathetic system takes over and lowers heart and breathing rate, diverts blood supply back to housekeeping e.g. digestion.

26
Q

components of a neurone?

A

from middle out:

axon: (long extension of a neurone that carries nerve impulses)

layers of lipids

—Nerves only!! (in peripheral NS)—

schwann’s cells: cells that produce myelin

myelin sheath: fatty substance that surrounds and protects some nerve fibres

node of Ranvier: gap in myelin sheath- where action potential occurs during saltatory conduction along the axon

27
Q

Kinds of neurones?

A

Bipolar- interneurone. specialized sensory neurons for the transmission of special senses. part of the sensory pathways for smell, sight, taste, hearing. retina and inner ear.

unipolar (sensory neurone). detect stimuli + transmit signal to CNS. afferent nerves. cell body lies outside of axon (from cell body, a projection that divides into two axon branches). quick signaling since it goes straight pass the cell body.

multipolar (motion neurone). transmits signals from CNS to effectors muscles/organs that acts in response to stimulus). *efferent nerves. *most nerves in CNS! 1 axon, several dendrites.

pyrimidial cell: found in the brain. from grey -> white.

not called nerves, called tracts.

28
Q

nervous system diseases?

A

Multiple sclerosis:

Degenerative autoimmune disorder. Meaning the body’s immune system is attacking itself. White blood cells attacking myelin sheaths, creating scar tissue. Sclerae = scars. Damage to somatic nerve system -> loss of bodily control. Scavenger cells called macrophages remove damaged myelin and interfer with the conduction of impulses.

Parkinson’s:

Degenerative condition affecting basal ganglion (pl. ganglia). *Ganglia are collection of nerve cells. Relay points and intermediary connections between different NS. *Basal ganglia help control bodily movement, but needs dopamine to function. Usually released by substansia nigira, but this is damaged in Parkinson’s disease.

29
Q

Nerve impulse theory

A

All or nothing law: the electrical impulse size does not change due to the size of the stimulus. you feel some things more strongly if more neurones sense it.

Resting potential is ~-70mV. It is made by the NaK membrane pump, requires ATP.

Level @ stimulus is strong enough to transmit: threshold. when reached, impulse travels along the entire length of the nerve fibre. transmission speed can vary: cold and damaged myelin sheaths slows down.

30
Q

sodium potassium pump?

A

3 Na+ out, 2K+ in. == inside of cell has negative charge.

1/3 of ATP in the mitochondria goes to keeping this going.

31
Q

Sending nerve impulses?

A

Action potentials: electricity caused by sudden reversal of potential.

1. “resting” neurone. resting potential- positive sodium ions are continuously pumped out from cell, inside of cell membrane negatively charged.

**2. **nerve impulse triggered. stimulated by an impulse, the cell membrane allows K+ ions to rush into the cell. at these local sites, the inside of the membrane becomes positively charged. reversal of charge, depolarization.

3. impulse continues. as the impulse moves along the axon, new segments become positively charged while those who were previously positive return to a negative state. repolarization. cell returns to resting potential, sodium gate closes.

4. target cell reached. the impulse reaches the synaptic knob, triggering the release of neurotransmitter molecules from the vesicles. the molecules cross the synaptic cleft, the synapse, to activate a response in the target cell. synaptic signaling

32
Q

purposes of endocrine system?

A
  • maintains homeostasis
  • cooperates w/ NS (coordinating center hypothalamus) to help body respond to stress
  • controls the body’s rate of growth and metabolism
  • controls sexual development + reproduction
33
Q

hormone definition

A

chemical messenger that is producd by cells or tissues of the endocrine system and that travels through the blood to act on target cells or target organs, before being broken down.

34
Q

property of nervous signals

A

nature of signal: nerve impulses

size of signal: frequency modulated

speed of signal: very rapid (mS)

effect in body: localized

capacity for modification: can be modified by stimuli (learning)

35
Q

properties of endocrine signals

A

nature of signal: hormones- chemical signals

size of signal: apmlitude modulated (modulation is control of signals)

speed of signal: can be rapid (adrenaline), can be slower (growth hormone). speed depends on amplitude.

effect in body: more generalized

capacity for modification: cannot be modified

36
Q

Feedback mechanisms?

A

A specific mechanism known as feedback controls hormone production. involves hypothalamus, pituitary gland and the target gland. a feedback system can either promote the release of another hormone (positive feedback) or inhibit its release (negative). this involuntary mechanism maintains a balance in the body.

1. response to hormone levels

responding to levels of thyroid hormone, the hypothalamus makes TRH. this stimulates the pituitary gland to release THS. the thyroid gland is then triggered to produce its hormones.

2. Negative feedback

↑x → ↑y → ↓x

if thyroid hormone levels are too high, negative feedback alerts the hypothalamus so that it produced less TRH. A lower level of TRH results in a lower level of THS. Thyroid responds by producing less hormone. picture shows negative feedback loop

3. Positive feedback

If thyroid hormone levels fall too low, the feedback mechanism is weakened. in respone, the hypothalamus makes more THR; the pituitary gland increases secretion of TSH and the levels of thyroid hormone also rise.

37
Q

mechanisms of hormone release?

A

**a. **humoral- in response to changing levels of ions or nutrients in blood

**b. **neural- stumulation by nerves (e.g. adrenaline)

c. hormonal- stimulation received from other hormones

38
Q

changes in hormone secretion through time?

A

a. chromic hormone regulation: maintenance of relatively constant concentration of hormone. thyroid hormone.

b. acute HR: epinephrine in response to stress

c. cyclic HR: gemale repdoductive hormones.

39
Q

what is pituitary gland?

A

a pea-sized gland which hangs from the underside of the brain and secretes hormones that help to control many of the other gland in the body. The master gland! controls many other endocrine glands in the body.

40
Q

examples of hormone the pituitary gland releases?

A

oxytocin: uterine muscles & mammary glands. stimulates the release of breast milk, uterine contractions during labour.

Growth hormone: bone and general growtn. acts on body to promote protein synthesis. essential for normal growth.

TSH- thyroid stimulating hormone: thyroid gland. widespread effecs on body metabolism.

Adrenocorticotropic hormone: adrenal gland. influences body’s response to stress, how body uses saccharides + lipids.

41
Q

important-to-know hormones!

A

prolactin: stimulates milk production after childbirth

glucagon: hormone produced in pancreas which promotes breakdown of glycogen to glucose in the liver.

42
Q

hormone classification?

A

1. Steroid hormones

  • small
  • hydrophobic / lipophilic
  • travel in blood w/ carrier. processed directly
  • cytoplasmic or nyclear receptors
  • change protein synthesis
  • example: progesterone (stimulates uterus to prepare for pregnancy)

2. Protein/peptide (non-steroid) hormones

  • hydrophilic
  • large
  • can’t fit through membrane
  • second messenger mechanism of action
  • most hormones!
  • example: insulin
43
Q

second messenger mechanism?

A

Since peptide/protein hormones can’t diffuse through lipid bilayer, they do this.

1. p/p hormone diffuses from capillary through intersitial fluid to target cell.

2. hormone binds to receptor (transmembrane protein)

3. G protein is stimulated.

4. GTP swaps for GDP.

5. G protein stimulates adenylate cyclase inside cell.

6. cAMP stimulates protein kinase

7. CREB: cyclic AMP responsive element binding protein. diffuses into nucleus & stimulates gene transcription.

tldr; hormone binds to receptor, then leaves, stimulates cAMP (second messenger) changes metabolism of cell.

Cyclic AMP: adenosine monophosphate. transformed ATP, lost 2 phosphates + formed cyclic sugar-phospho complex. it is used like this because ATP is used for such a wide array of things. it would be bad if the signal got confused.