Test 2 Flashcards
What are neurotransmitters?
An electrical impulse through the neuron stimulates its release into the synaptic cleft, which in turn determines whether another electrical impulse is generated
What are chemicals that are stored in the axon terminals of the presynaptic neuron?
Neurotransmitters
What are receptors?
Molecules situated on the cell membrane that are binding sites for neurotransmitters
What is reuptake?
The process of neurotransmitter inactivation by which the neurotransmitter is reabsorbed into the presynaptic neuron from which it had been release
What is an amino acid neurotransmitter?
Gamma-amino-butyric acid (GABA)
How do antidepressants work?
Block reuptake of neurotransmitters
How do antipsychotics work?
Block dopamine and other receptors
How do benzodiazepines work?
Facilitate transmission of GABA
How do psychostimulants work?
Increase release of neurotransmitters
What happens with schizophrenia?
There is a severe deterioration of social and occupational functioning
Complex disorder effecting: cognition, emotions, and behaviors
What are the 5 predisposing factors in schizophrenia?
1) Genetics
2) Biochemical
3) Physiological
4) Sociocultural
5) Stressful life events
What is the dopamine hypothesis?
Hyperactive dopamine transmission results in schizophrenic symptoms
What are the 4 phases of schizophrenia?
1) Pre-morbid
2) Prodromal
3) Active/psychotic
4) Residual
What is the pre-morbid phase?
The individual is started to withdraw from society
Becoming more anti-social, relationships suffer, doing poor in school, irritable
What is the prodromal phase?
Average length is 2-5 years
Not eating, showering, sleeping and no social relationships
Phase ends in psychosis (out of touch with reality)
What is the active phase?
Delusions, hallucinations and disorganized behavior
True disconnect from reality (positive and negative symptoms)
What is the residual phase?
Acute symptoms of active phase are absent
Some negative symptoms that remain - can impair role function (empathy)
What are the two symptom clusters?
Positive and negative
What are positive symptoms?
Disorganized thoughts
Altered perceptions
What are altered perceptions? +
Hallucinations and sense of self
What are the 8 negative symptoms?
Affect Apathy Anhedonia Ambivalence Anti-Social Anergia Avolition Alogia
What is affect? -
Diminished emotional expression
What is apathy? -
Disinterest in daily activities like socializing, working or going to school
What is anhedonia? -
Diminished capacity to experience pleasant emotions
What is ambivalence? -
The tendency for the schizophrenic mind to make two affective attitude of two opposite ideas interact at the same time
What is anergia? -
Chronic state of lethargy and low energy
What is avolition? -
Lack of motivation or ability to do tasks or actives that have an end goal
What is alogia? -
Disruption of the thought process that leads to a lack of speech and issues with verbal fluency
What are delusions? +
A false belief that the patients think is real
What is persecution delusion? +
When an individual is convinced that someone is mistreating, conspiring against, or planning to harm you or your loved one
What is grandeur delusion? +
A person’s belief that they are someone other than who they are, such as a supernatural figure or celebrity
What is reference delusion? +
A neutral event that is believed to have a special and personal meaning
What is control/influence delusion? +
External forces in the environment and have control over them
What is somatic delusion? +
Fixed false beliefs that one’s bodily function or appearance is grossly abnormal
What is nihilistic delusion? +
Delusional belief of being dead, decomposed, annihilated or having lost one’s internal organs
What is religiosity? +
Excessive demonstration of obsession with religious ideas and behavior
What is paranoia? +
Extreme suspiciousness of others
What is magical thinking? +
Ideas that one’s thoughts or behaviors have control over specific situations