Test 2 Flashcards
Effect where the elastic recoil of the aorta helps to “dampen” or “smooth out” the pulsatile flow of blood out of the left ventricle of the heart
Windkessel Effect
The there layers of arteries
Tunica intima Tunica media Tunica externa (or adventitia)
Blood flow through arteries is affected by two major variables What are they?
pressure and resistance.
Q=∆P/R
the force with which blood is pushed against the walls of blood vessels
Blood Pressure
highest amount of pressure reached during ventricular ejection of blood
Systolic Pressure (SP)
minimum amount of pressure just before ventricular ejection begins
Diastolic Pressure (DP)
potential energy is then released by the RECOIL of the arterial wall, which propels the blood distally and provides the________This alteration of systolic and diastolic propulsion provides a more continuous (rather than pulsatile) flow to the peripheral tissues. This pressure-storing property of the aorta is sometimes called the ______ effect.
“diastolic runoff”
“Wind Kessel”
Auscultatoric measurement devices determine blood pressure by monitoring…
Korotkoff sounds
These measurements use an electronic pressure sensor with a numerical readout of blood pressure.
Oscillometric measurement device
Mean Arterial Pressure (MAP) =
2/3 DP + 1/3 SP
or
MAP = DP + 1/3 PP
the sum of all resistance in the vasculature
Total Peripheral Resistance (TPR) or Systemic Vascular Resistance (SVR)
There are 3 important sources of resistance within a single vessel:
- blood viscosity
- vessel length
- vessel diameter or radius
The relationship between resistance, viscosity, vessel length, and vessel radius is explained with
Poiseuille’s Law.
POLYCYTHEMIA
high hematocrit state
Another factor that is influences viscosity is the tendency of RBCs to aggregate into stacks called…
ROULEAUX
in blood flow Resistance=?
R = 8 V L / π r^4
Baroreceptors are neural receptors located in the…
CAROTID SINUS and AORTIC ARCH
Which cranial nerves carry signals from baroreceptors?
Cranial nerves IX (glossopharyngeal) and X (vagus)
What center of the brain processes signals from baroreceptors?
MEDULLARY CARDIOVASCULAR (or CARDIOREGULATORY) CENTER of the brainstem
Medullary Cardiovascular Center Functions
Makes decisions about what to do about hypertension or hypotension…..and then employs the services of the SNS and ParaNS to send those orders to various target tissues
Why would baroreceptors get used to high BP?
decreased sensitivity of the baroreceptors to increases in arterial pressure or an increase in the blood pressure set point of the brainstem centers.
A decrease in renal perfusion pressure (blood pressure) causes kidneys to secrete this enzyme
RENIN
Renin catalyzes the conversion of
ANGIOTENSINOGEN to ANGIOTENSIN I in the plasma
catalyzes the conversion of angiotensin I into ANGIOTENSIN II
ANGIOTENSIN CONVERTING ENZYME (ACE)
Hypovolemia, or volume contraction ( e.g., due to hemorrhage), is also a potent stimulus for…
ADH secretion
ADH has 2 effects that tend to increase blood pressure toward normal. What are they?
It increases water reabsorption via the kidneys activates V_2 Receptors
It is a potent vasoconstrictor that increases TPR by activating V_1 Receptors
The responses to an increase in blood volume include:
- increased secretion of ANP
* decreased secretion of ADH
This hormone is secreted by the atria in response to increased atrial pressure
ANP
Effects of ANP
• Causes relaxation of vascular smooth muscle, which results in
vasodilation and decreased TPR
• In the kidney, this vasodilation leads to increased Na+ and water excretion, thereby decreasing total body Na+ content, ECF volume and blood volume
Hypertensive cases are classified as secondary when?
Caused by a disorder or situation that increases TPR or CO, e .g.