Test 2 Flashcards
Name the 2 natural anti-fungals- what does this mean
Amphoteracin B and griseofulvin- made by other fungi
Name the three main types of synthetic antifungals
Azoles, allylamines, flucytosine
Griseofulvin- MOA
disrupts mitosis
Griseofulvin- primary usage
With a topical for dermatophytosis
Griseofulvin- administration and absorption
oral with variable absorption that taking with fatty meal will improve
Griseofulvin- SE
V, D, anorexia, BM suppression, teratogenic
Amphoteracin B- MOA
Binds sterols (selective for ergosterol) to increase cell wall permability
Amphoteracin B- administration and absorption
Poor oral, give IV via slow infusion; do not approach max cumulative dosing
Amphoteracin B- SE
NEPHROTOXIC- always monitor renal values
Purpose of Amphoteracin B in lipid-bound form
reduced nephrotoxicity
CS of Amphoteracin B toxicity
V, myalgia, fever, anphylaxis
Which form of Amphoteracin B is anphylaxis more common
lipid bound
Amphoteracin B- spectrum and PK/PD info
Effective against most fungi; poor penetration in things with barriers (bone, brain/CSF, aqueous/vitreous)
Name non-lipid complexed Amphoteracin B
Amphoteracin deoxycholate (fungizone)
What type of drug is Amphoteracin deoxycholate (fungizone)
Natural, non-lipid complexed
