Test 2 Flashcards
Normal pH range of blood.
7.35-7.45
Is the blood slightly acidic or slightly basic?
Slightly basic
Total liters of blood: ____L
5
Approximately how many gallons of blood are there in an adult?
1.2 - 1.5 gallons
Is plasma extracellular or intercellular fluid?
Extracellular
Which of the four basic types of tissue is blood?
Connective tissue
What are the two components of whole blood?
Formed elements/cell and cell fragments + plasma
 what makes up plasma?
 water,  solutes: gases, hormones, enzymes, waste products, ions
List all the plasma proteins.
Albumin, fibrinogen, globulins, other clotting factors
What does albumin do?
Plays a role in maintaining osmotic pressure.
What is osmotic pressure?
Force which water moves across a membrane, due to a concentration gradient
When there is a lot of albumin in the blood, is osmotic pressure high or low?
High
What does fibrinogen do?
Clot blood
What are globulins?
Antibodies and transport proteins
What are erythrocytes?
Red blood cells
What do red blood cells do generally?
Carry oxygen in the bloodstream
What is a leukocyte?
A white blood cell
What do white blood cells generally do?
Immune function
What are thrombocytes?
 platelets
What do platelets do?
Clotting function
Which type of blood cell is the most numerous formed element?
Red blood cells
What is the ratio of red blood cells to white blood cells?
1000:1
What is the ratio of red blood cells to platelets?
10:1
What is a Hematocrit?
The percent of red blood cells in whole blood (38-55% - varies with age and sex)
When whole blood is centrifuged it separates into cells at the bottom of the tube and _____________ at the top. The white blood cells and platelets create a Buffy coat in between the plasma and red blood cells.
Plasma
The percentage volume of red blood cells relative to the volume of the total liquid is called the ___________.
Hematocrit
Define hematopoiesis.
Whole blood formation (Red blood cells, white blood cells, platelets)
Define erythropoiesis.
Red blood cell formation
All blood cells are made in the adult in the ___________.
red bone marrow
Where is red bone marrow located?
In flat bones and in Epiphyseal ends of long bones
In the fetus, blood cells are made in the _________, __________, and _________.
Liver, spleen, thymus
Define Leukopoiesis.
Formation of white blood cells
All blood cells (erythrocytes, leukocytes, and thrombocytes) are derived from the same ______________________.
Hematopoietic stem cell
Depending on which external factors act on it, the hematopoietic stem cell can become one of the following cells:
Red blood cells, white blood cells, platelets
Can hematopoietic Stem cells undergo mitosis?
Yes
Can hematopoietic stem cells become different types of blood cells?
Yes
How does the stem cell know which type of cells become?
Colony stimulating factors and hormones
What are the two growth factors acting on bone marrow cells that affect growth of certain cells?
 erythropoietin and colony stimulating factors
What is erythropoietin?
Hormone made by the kidney when oxygen is low
Erythropoietin _____(increases/decreases)____ erythropoiesis in the bone marrow.
 increases
What do colony stimulating factors do?
Primarily increase growth of blood cells
What is the size of a red blood cell?
7-8 um
How long do red blood cells live?
120 days
In which organs are Red blood cells destroyed?
Spleen and liver
Which cells in the liver sinusoid destroys old red blood cells?
Kupffer cells
What is a reticulocyte?
A cell that is made in the next to last step of erythropoiesis that loses its nucleus to become a red blood cell
When the rate of Erythropoiesis is high a __________ Number of reticulocytes are found in the blood.
High
Which vitamins are important for erythropoiesis?
Folate, vitamin B12, iron
What happens to iron in hemoglobin when it’s broken down?
Iron is salvaged and recycled
What happens to heme in hemoglobin when it is broken down?
Heem forms Bilirubin
What happens to globin in hemoglobin when it is broken down?
Globin is made of amino acids which are broken down
Do red blood cells have nuclei?
 no
Do red blood cells have mitochondria?
No
How do red blood cells produce ATP?
Glycolysis
How many blood cells are there per mm^3
5 million/mm^3
What is polycythemia?
Too many red blood cells which causes thick blood which causes blood clots
What is anemia?
Reduced oxygen carrying capacity of the blood caused by iron deficiency or blood loss
What is a hematocrit?
Percentage of erythrocytes in whole blood sample
What is the normal value of a hematocrit?
Between 38 and 55
Does the value of the hematocrit have units?
No, not really, but usually reported as a percent
How prevalent is hemoglobin in the red blood cell?
95% hemoglobin in red blood cell
What Is oxyhemoglobin? What color is oxyhemoglobin?
Bright red hemoglobin that is carrying oxygen
What element binds to oxygen and hemoglobin?
 Iron
How many oxygen molecules combine to one hemoglobin molecule?
4
What is normal hemoglobin for women and for men?
Women: 12 - 15 g/dL
Men: 13 - 17 g/dL
What is carbaminohemoglobin?
Hemoglobin and carbon dioxide attached
What symptoms or signs are present in anemia?
Fatigue, fast heart rate, shortness of breath
What is hemorrhagic anemia?
Red blood cells are destroyed faster than they are made
What is hemolytic anemia?
Red blood cells are breaking apart caused by sickle cell or infection. Hemolytic anemia causes jaundice.
What is Aplastic anemia?
The inability to make bloods cells in the bone marrow
What is pernicious anemia?
Lack of vitamin B 12/intrinsic factor
What is iron deficiency anemia?
Caused by blood loss
What is sickle cell anemia?
Abnormal hemoglobin that causes red blood cells to sickle when exposed to low oxygen, stopping up circulation
If the anemia is due to a loss of red blood cells, with the hematocrit be low or high?
Low
What do antigens do?
Causes an immune response
What are found on the surface of red blood cells and determine blood type?
 glycoproteins and glycolipids (proteins with sugars or fats attached)
Also called agglutinogens
What does agglutinate mean?
Clump together
The body recognizes its own surface antigens as “_____________” and does not attack its own surface antigens.
 self
If blood is received from someone else with different antigens, the immune system will attack those cells, it does so through plasma proteins called _______.
Antibodies
The Rh factor (D antigen) makes the blood type __________ or __________.
Negative or positive
Only glycolipid (antigen) A is present on the red blood cell = blood group ______
A
Only glycolipid (antigen) B is present on the red blood cell = blood group ______
B
Both glycolipids (antigens) A and B are present on the red blood cell = blood group ______
AB
Neither A nor B glycolipids (antigens) are present = blood group _______
O
Each blood type has ____________ in the plasma against the A or B antigens it does not possess.
Antibodies
Blood group a house which antibodies?
Anti-B
Blood group B has which antibodies?
Anti-A
Blood group oh has which antibodies?
Both a and B antibodies
Blood group AB has which antibodies?
No antibodies
Can a persons blood type change?
No
If the D antigen is present, the person is _______.
Positive
If the D antigen is not present, the person is __________.
 negative
The __________ present on the red blood cell determine the blood type..
Antigens
If the A and D antigens are present, the person would have ________ blood.
A+
If the A and B antigens are present but the D is not, the person would have __________ blood
AB-
There are no antigens on the red blood cell but a and B antibodies, what is the blood type?
O-
There are only D antigens on the red blood cell. What is the blood type?
O+
Could an Rh- Person receive Rh+ blood one time?
Yes, But only one time because it is not until the Rh negative person makes antibodies after one exposure that the person is in danger of a transfusion reaction.
Rh+ blood is never given to a Rh- patient in a clinical setting. True or false?
True
When looking at blood compatibility, the donor’s _________ and the recipients __________ Are significant.
Red blood cells; antibodies
Can a person with A+ blood receive blood from AB+?
No, because the B antibodies will react with the B antigen on the donors red blood cells.
Can a person with B- blood receive blood from O-?
Yes, because there are no antigens on the donor red blood cells, so there will be no reaction with the recipients A antibodies.
What blood type is the universal donor?
A person with O- blood can donate to any blood type, because O- has no antigens.
Which blood type Is the universal recipient?
A person with AB+ blood can receive from any blood type, because AB+ has no antibodies.
Can B + blood donate to AB +?
Yes, AB+ is the universal recipient
Can AB+ blood donate to O+?
No
Can O+ blood donate to AB+?
 yes
Can B+ blood donate to B-?
No
Most people are Rh__
+
RH negative mothers can become pregnant with Rh positive children. The problem will be with the next pregnancy, assuming she is carrying an RH positive child. The mother now has ________. they would cross the placenta and clump The babies blood. That can lead to devastating effects in a condition called ______________ _________.
D antibodies; erythroblastosis fetalis
Mothers who are Rh negative are given _________ before and after delivery.
Rhogam
What is Rhogam?
It contains D antibodies. It prevents the mother from building her own antibodies. Because the mother did not build up any D antibodies of her own, she can carry a second Rh positive child.
Do leukocytes have nuclei?
 yes
Do leukocytes have hemoglobin?
No
How does the size of a white blood cell compared to a red plet cell?
White blood cells are double the size as red blood cells. They are BIGGER!
What is the significance of histocompatibility proteins on the surface of white blood cells?
For immune system response
What is the major histocompatibility complex?
Coding region for surface proteins
How many white blood cells per mm^3?
5,000-10,000/mm^3
What is the clinical term for too many white blood cells?
Leukocytosis
What is the clinical term for two few white blood cells?
Leukopenia
How do you a granular and granular leukocytes differ?
Granular leukocytes have granules in the cytoplasm
Where are granular Leukocytes made?
Red bone marrow