Test 1 Flashcards
What is the difference between the actual gastrointestinal tract and the accessory digestive organs?
The actual gastrointestinal tract must have a lumen through which food passes, while food does not pass through accessory digestive organs.
Name the structures of the alimentary canal (actual G.I. tract) from the mouth to the anus.
Mouth, oropharynx, Laryngopharynx, esophagus, stomach, duodenum, jejunum, ileum, cecum, ascending colon, transverse colon, descending colon, sigmoid colon, rectum, anus
Give examples of accessory digestive organs.
Salivary glands, liver, gallbladder, pancreas, teeth, tongue
What is ingestion?
Intake of food and/or liquids
What is mastication?
Chewing
Name a skeletal muscle that closes the mouth.
Masseter muscle
Which cranial nerves are involved in mastication?
Trigeminal (5)
What is deglutition? 
 swallowing
Which cranial nerves are involved in deglutition?
Trigeminal, facial, glossopharyngeal, Vagus, Hypoglossal
Does deglutition involve smooth muscle, skeletal muscle, or both? Explain.
Both, moving bolus from the oral cavity to the oropharynx is voluntary, but smooth muscle involuntarily moves bolus to the esophagus and then to the stomach by peristalsis.
What is mechanical digestion?
Physical grinding of food (mastication) to create more surface area for chemical digestion.
What is chemical digestion?
Enzymes are secreted in the mouth stomach and duodenum to chemically break down compounds due to the addition of water (hydrolysis)
Chemical digestion occurs by a process called hydrolysis. What does that mean?
Hydrolysis is the chemical breakdown of compounds due to the addition of water.
Is water a reactant or a product in a hydrolysis reaction?
Reactant
What is absorption?
Chemicals (monosaccharides, amino acids, fatty acids, Monoglycerides) move into the bloodstream.
Where does most absorption occur in the G.I. tract?
The small intestine, particularly the jejunum.
Where does food go once it is absorbed?
Liver
What is defecation?
Ridding of waste (fecal matter) which usually contains cellulose (which cannot be absorbed).
What is a peritoneum?
Serous membrane that lines the abdominal cavity and organs
What is a serous membrane? Name the two tissues that make up a serous membrane.
It secretes water.
- Simple squamous
with - Areolar tissue and blood vessels
underneath
What is parietal peritoneum?
Attached to wall of the abdominal cavity
What is visceral peritoneum?
Located directly on organs in the abdominal cavity
The space between the parietal peritoneum layer and the visceral peritoneum layer is called the ______________________. What does it do?
Peritoneal cavity; it contains fluid to reduce friction between organs
What is meant by intraperitoneal and retroperitoneal organs? Give examples of each.
Intraperitoneal organs are inside the abdominal cavity. (Ex:  stomach, spleen, liver, first and fourth parts of the duodenum, jejunum, ileum, transverse, and sigmoid colon)
Retroperitoneal organs are behind the abdominal cavity. (Ex: kidneys, adrenal glands, aorta, pancreas, duodenum, lymph nodes, prostate, vagina, rectum, inferior vena cava, ascending colon, descending colon
Parietal and visceral peritoneum are connected by folds of tissue called _______________. 
Mesentery
Where is the greater omentum located?
Fatty apron hanging down from the stomach
Where is the lesser omentum located? Which important blood vessels are located in the lesser omentum?
Between the stomach and the liver; hepatic portal vein, hepatic artery, lymph vessels
Where is the falciform ligament located?
It connects the liver to the diaphragm.
Where is the mesocolon located?
It connects the transverse colon to the parietal peritoneum.
Where is the mesentery proper located?
It connects the small intestine to the parietal peritoneum.
Which important blood vessels are found in the lesser omentum?
The hepatic artery, the portal vein, and lymph vessels
The walls of hollow organs (organs with a lumen) generally contain the four basic layers described below:
1. Mucosa: The mucosa is the layer that comes in contact with food (luminal side). The mucosa has three tissue layers. What type of tissue is found in each layer?
A.  epithelium
B. Lamina propria
C. Muscularis mucosa
A.  epithelium: (closest to free surface) simple columnar epithelium
B.  lamina propria: (contains blood vessels) loose areolar connective tissue
C. Muscularis mucosa: (Controls shape of mucus membrane) smooth muscle
The walls of hollow organs (organs with a lumen) generally contain the four basic layers described below:
- Submucosa with nerve plexus(submucosal or Meissner plexus): The nerve plexus of the submucosa regulates glands and the muscularis mucosa, and epithelium to regulate secretion.
- Submucosa: areolar connective tissue (Contains larger blood vessels that branch into lamina propria’s smaller vessels)
The walls of hollow organs (organs with a lumen) generally contain the four basic layers described below:
- Muscularis externa (2 layers?)
A. Inner circular layer of muscle- smooth muscle
B. Outer longitudinal layer of muscle- smooth muscle
Both work to achieve peristalsis.
Sandwiched between the circular and longitudinal layers is the _________________________ that carries impulses for the smooth muscle of the muscularis externa.
Myenteric (Auerbach) plexus
The walls of hollow organs (organs with a lumen) generally contain the four basic layers described below:
- Serosa or adventitia
4.  Serosa (Intraperitoneal organs): areolar connective tissue with simple squamous mesothelium
or
adventitia (retroperitoneal organs): Areolar connective tissue
Define the endocrine system.
Hormones secreted into the blood to act on a specific target organ.
Define the nervous system.
Nervous control of the digestive system involves intrinsic nerves (enteric nervous system) and extrinsic nerves (parasympathetic and sympathetic nervous systems)
Define the autonomic nervous system.
Parasympathetic, sympathetic, and enteric nervous systems. The autonomic nervous system can influence the enteric nervous system.
The parasympathetic nervous system ______________ motility and secretion in the G.I. tract.
 increases
The major Parasympathetic nerve intervating gastrointestinal organs is the _______  nerve.
 Vagus
The sympathetic nervous system ____________ motility and secretion in the G.I. tract.
 decreases
The enteric nervous system also includes _____________________ that can detect the presence of certain foods (chemo receptors) or stretch of an organ (stretch receptors)
sensory neurons
The ________ __________ _________ in the G.I. tract helps control motility and secretion. It includes both myenteric plexus and the submucosal plexus listed previously.
intrinsic nervous system
The enteric nervous system is influenced by the _______________ and ______________ nervous systems.
Parasympathetic; sympathetic
Define labia.
Lips
Define labial frenulum.
Tissue connecting the lips to the gums and bones.
Name the tissues found in the gingiva.
Keratinized Stratified squamous epithelium
What’s two bones make up the hard palate?
The Maxilla and Palatine processes
Why would the epithelium of the gums and the epithelium overlying the hard palate be partially keratinized stratified squamous epithelium?
To protect from abrasion from food.
What is the soft palate significance?
It lifts up to seal off the nasopharynx when swallowing.
What is the purpose of the uvula?
Works with soft palate to prevent food from entering the nasal cavity.
What is the purpose of the tongue.
The tongue, anchored to the hyoid bone, helps to create a bolus, and by mixing food with saliva.
Which cranial nerve innervates tongue muscles?
Hypoglossal
What is the purpose of the lingual frenulum?
It anchors the tongue to the floor of the mouth.
What is a bolus?
A ball of food in a specific shape to be swallowed
Name two functions of papillae located on the tongue.
They roughffin the tongues surface and they hold taste buds.
What is the function of the tonsils?
They gather and remove pathogens entering the pharynx in food or in the inhaled air.
Where are the parotid glands located?
Inside the retro mandibular fossa; posterior to the masseter muscle, inferior to the zygomatic arch, anterior to the sternocleidomastoid muscle
Where are the submandibular glands located?
Under the mandible.
Where are the sublingual gland located?
Under the tongue.
Which of the salivary glands has the longest duct?
The parotid glands
What type of cells make up parotid glands?
Serous cells
What type of cells make up submandibular glands?
Combination of serous cells and mucous cells.
What type of cells make up sublingual gland’s?
Mucous cells.
What are some functions of saliva?
Lubricate the mouth, initiate digestion process, ward off bacteria
Name at least 4 key components of saliva:
- Water
-  mucus
- Ions (Na+, K+, Cl+)
- Lysozyme and antibodies
What is the function of the enzyme, Amylase?
Breakdown carbohydrates
Where is amylase made?
Salivary glands (parotid) and The pancreas.
What is the optimal pH for Amylase?
7.0
By what process does amylase break down carbohydrates?
Hydrolysis
How is salvation controlled?
By the parasympathetic nervous system
Which cranial nerves innervate the salivary glands?
Facial and glossopharyngeal
Does parasympathetic stimulation increase or decrease secretion of saliva?
Increases
Which two bones have alveolar sockets for teeth
Maxilla and mandible
What are the functions of the incisors?
Biting, cutting
What is the function of the molars?
Grinding
What is the function of the canines?
Tearing
The number of secondary adult teeth generally follows the same dental formula for the top and bottom jaw: 4 incisors + 2 canines + 4 bicuspids+ 6 molars. this means adults have a total of _______________ teeth.
32
What are deciduous primary teeth?
Baby teeth
The number of deciduous teeth generally follows the same dental formula for the top and bottom jaw: 4 incisors + 2 canines + 4 molars. How many deciduous teeth are found in children?
20
Name each part of the pharynx below and the type of epithelium that is present:
- Nasopharynx- Pseudostratified columnar ciliated epithelium
- Oropharynx- stratified squamous epithelium
- Laryngopharynx- stratified squamous epithelium
Which parts of the pharynx are passageways for both food and air?
Oropharynx; laryngopharynx
Does the pharynx have skeletal or smooth muscle?
Skeletal muscle
The esophagus is ___________ inches long and located in the ____________________.
10;  mediastinum
What is the significance of the upper and lower esophageal sphincter’s?
The upper esophageal sphincter is made up of skeletal muscle. The lower esophageal sphincter is made up of smooth muscle. The upper esophageal sphincter closes after food enters and the lower esophageal sphincter opens.
Name the place where the esophagus perforate the diaphragm?
Esophageal hiatus
Is the esophagus anterior or posterior to the larynx and trachea?
Posterior
What are the four histological layers of the esophagus? What is unique about each layer that helps the esophagus perform its function?
-  mucosa- secretes, absorbs, protects
-  submucosa- secretes mucus
- Muscularis externa- peristalsis by circular and longitudinal layer contractions
- Serosa- reduces friction
Why is it significant that the upper esophagus contain skeletal muscle?
For voluntary swallowing
Deglutition involves three major phases. State what happens in each phase
A. Buccal (voluntary)- makes bolus of food and pushes into oropharynx
B. Pharyngeal (voluntary)- bolus passes through and stimulates tactile receptors/swallow reflex -> Trigeminal and glossopharyngeal -> swallow center(medulla oblongata) -> epiglottis folds and closes off respiratory tract -> food is directed towards esophagus
C. Esophageal (involuntary)- constrictor muscles of the Pharynx contract, forcing food into the esophagus inferiorly. Upper esophageal sphincter contracts (closes) after entry.
 What type of epithelium is found in the stomach mucosa?
Simple columnar epithelium
What is a gastric pit? How does it differ from a gastric gland?
Gastric pit: holes in the lumen of the stomach that branch into gastric glands.
What is the purpose of mucous cells in the lumen?
Protect against acidic gastric juices
List two products of parietal cells in the glands. What function does each product have?
1. H+- creates pH of 3 acidic stomach juices
2. Intrinsic factor-  aids in absorption of vitamin B12 (needed for red blood cell production and nervous function)
What is the zymogen (proenzyme) Made by chief cells in the glands?
Pepsinogen
Hydrochloric acid activates pepsinogen to pepsin. True or false?
True.
Why is the product of chief cells in the glands secreted in an inactive form?
It is important that pepsin is not activated until it reaches the lumen to mix with food or else it will digest the cell membrane of simple columnar cells.
What activates pepsinogen? What does it digest once it is activated?
Hydrochloric acid; pepsin digest proteins by hydrolysis
Name a product of the endocrine G-cells in the gastric glands of the stomach.
Gastrin (flows into blood vessels of lamina propria, goes through the body, comes back to the stomach to act on parietal cells to cause more acid to be made)
In general what is meant by the term enteroendocrine cell?
Intestinal hormone secreting
What type of tissue is found in the submucosa of the stomach
Loose connective tissue in the stomach
Dense irregular connective tissue is found in the esophagus, large intestine and small intestine
What are Ruege? Are Ruege folds of mucosa only or mucosa and submucosa?
Ruege are large visible mucosa and submucosa folds
Name the additional layer of muscularis externa present in the stomach.
1. Inner circular
- Outer longitudinal
- Inner oblique layer
Why does the stomach have three layers of muscularis externa?
For the mechanical processing of food to make chyme
Which layer of muscularis is closest to the submucosa?
Inner oblique layer
What types of tissues are found in the serosa of the stomach
Simple squamous mesothelium and connective tissue
What is the normal pH of stomach juice
pH 3
Is the hydrogen ion pump in the parietal cell membrane on the luminal side of the cell?
Yes
What parts of the small intestine are intraperitoneal and which are retroperitoneal?
Duodenum-  retroperitoneal
Ilium, jejunum-  Intraperitoneal
How long is the small intestine
18ft
What are microvilli (brush border)?
Folds of the cell membrane
What are villi?
Folds of the mucosa only
What are Plicae Circulares(Circular folds)?
Folds of the mucosa and submucosa.
Can plicae circulares easily be seen with the naked eye?
Yes
What kind of epithelium is found in the mucosa of the small intestine?
Simple columnar (for absorption)
Why are there so many goblet cells in the mucosa of the small imtestine?
To create a layer of mucus to protect stomach from acid
What is found in the laminapropria of a villus?
Extensive network of capillaries
What is a lacteal? What is its purpose?
It’s a lymph vessel- absorption of fat and transports materials that can’t enter the blood capillaries
Why does the small intestine have a brush border?
To increase surface area for food absorption
The individual extensions of the brush border are actually _____________.
Microvilli
Are enzymes embedded in the brush border? If so, name them.
Lactase, sucrase, maltase, dipeptidase
Where are intestinal glands (crypts of Lieberkühn)?
Deep between the villi
Which hormones are made by Enteroendocrine cells of the small intestine?
Secretin and CCK
Name a product of Paneth cells and its significance
Lysozyme -> antibiotic to prevent bacterial invasion into the lamina propria, submucosa, and bloodstream
Duodenal (Brunners) glands make _______________. Why?
Mucus; to provide protection from acid and neutralize stomach acid. 
ileum: aggregated lymphoid nodules (Peyer’s patches) consist of cells that ______ _______.
Destroy bacteria
Are lymphatic nodules only located in the ileum? What are lymphatic nodules?
No; aggregates of white blood cells
Blood that comes to the liver comes from two places:
- Oxygenated blood from the aorta (via the hepatic artery)
2. Deoxygenated blood with absorbed foods from the small intestine a (hepatic portal vein)
Both vessels (The hepatic artery and the hepatic portal vein) travel to the liver through a fold of peritoneum called the ________ ________.
Lesser omentum
_______________ contain blood that comes from branches of the hepatic portal vein and hepatic artery.
Sinusoids
The blood from the ________________ brings oxygen.
Hepatic artery
The blood from the ____________________ entering the sinusoid contains absorbed nutrients
Hepatic portal vein
What happens to excess carbohydrates when they are brought to the liver?
Broken down to glucose - Source of energy 
What happens to excess amino acids when they are brought to the liver?
Forms ammonia
What does the liver do with toxic substances that are absorbed into the blood in the small intestine?
Filtered by kidneys and leave body as urine
________ contain bile that is leaving the liver.
Bile canaliculi
What is the only digestive function of the liver?
Liver makes bile to allow enzymes of the pancreas to digest/emulsify fat easier
What is the function of bile?
Emulsify fats
Which cells make bile?
Hepatocytes
Describe what is meant by the term emulsification.
Breakdown fat into small droplets.
Bile contains…
Water, bile salts, bile pigment bilirubin, cholesterol
What is the function of bile salts
Emulsifies fat
Where does bile pigment come from?
It’s a breakdown product of hemoglobin in red blood cells
Bile flows from the common hepatic duct into the ________________ duct and then to the gallbladder.
Common bile
Before bile enters the duodenum the common bile duct merges with the _________.
Cystic duct
What is the hepato-pancreatic ampulla (ampulla of Vater)
Small opening that enters into the first portion of the small intestines
What is the significance of the hepato-pancreatic sphincter (sphincter of Oddi)?
Controls the entry of bile and pancreatic juices
Where is the gallbladder located?
Hangs off the liver - connected to bile ducts by cystic duct
Is the gallbladder an intraperitoneal or retroperitoneal Organ?
Intraperitoneal
Why does the gallbladder have rugae?
Allow for expansion
What happens to bile in the gallbladder.?
Stored and concentrated
What causes the gallbladder to release bile?
When we eat a lot of fat, CCK secretes, and the gallbladder contracts
What makes the duodenum secrete cholecystokinin (CCK)?
When fat enters duodenum
Can a person live without a gallbladder? What consequence would it have for a person not to have a gallbladder?
Yes;  diarrhea
Why do you gallstones often develop in the gallbladder?
Bile becomes too concentrated
Name some common components of gall stones
Cholesterol, Bile salts, bilirubin
What part of Deglutition is voluntary?
The buccal phase in the pharyngeal phase are somatic.
What part of deglutition is involuntary?
The esophageal phase is autonomic.
What is the role of the soft palette in Deglutition?
Closes off the nasopharynx to prevent food from entering airway.
Where is deglutition controlled?
Medulla oblongata
What is peristalsis?
Smooth muscle contractions “milk” food through the digestive tract due to the contraction of circular and longitudinal layers in the muscularis externa.
What plexus is located between the circular and longitudinal layers of the muscularis externa?
Myenteric plexus
To which nervous system does the myenteric plexus belong?
Enteric nervous system