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Nurs 729 Psych Nursing > Test 1 Psych Meds: MDD & Schizophrenia > Flashcards

Test 1 Psych Meds: MDD & Schizophrenia Flashcards

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1
Q

What are the major SSRI drugs?

A

Fluoxetine (Prozac)
Sertraline (Zoloft)
Paroxetine (Paxil)
Citalopram (Celexa)
Escitalopram (Lexapro)
Fluvoxamine (Luvox)

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2
Q

What conditions are SSRI drugs used to treat?

A

MDD
OCD
Bulimia
Panic Disorders
PTSD
Pre-menstrual dysphoria

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3
Q

What are the adverse side effects of SSRIs?

A

Suicidal Ideations
Respiratory Distress
Sexual Dysfunction

Risk of Serotonin Syndrome***

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4
Q

What are the TCA drugs?

A

Nortriptyline (Pameleor)
Amtitriptyline (Elavil)
Imipramine (Tofranil)`

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5
Q

What conditions are TCAs used to treat?

A

Depression
Insomnia
Neuropathic pain
Depressive phase of bipolar illness

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6
Q

What are the adverse effects of TCAs?

A

High Lethality potential (can easily overdose)
Suicidal Ideations
Anticholinergic Effects

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7
Q

What are the MAOI Drugs?

A

Isocarboxazid (Marplan)
Phenelzine (Nardil)
Selegiline (EMSAM)
Tranylcypromine (Parnate)

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8
Q

What are some important education points for patients taking MAOIs?

A

Avoid foods with Tyramine
MAOIs have MANY med interactions so be sure to check with provider before starting any new meds

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9
Q

All the antidepressants are at risk of serotonin syndrome except for?

A

The aytipical antidepressants

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10
Q

What are the first generation antipsychotics?

A

Chlorpromazine (Thorazine)
Haladol

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11
Q

What are the pharmacokinetics of FGAs?

A

Dopamine Recepetor Antagonist
Muscarinic antagonist to the receptors for acetylcholine, norepinephrine and histamine

*Knowledge connection-If FGAS are muscaranic antagonists for histamine, how do we treat psuedoparkonism that can be caused by FGAs?
(Answer located in outline)

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12
Q

What symptoms of schizophrenia to FGAs target?

A

Positive symptoms only

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13
Q

What are the disadvantages/adverse effects of FGAs?

A

Extrapyramidal side effects
Anticholinergic side effects
Tardive Dyskinesia
Orthostatic hypotension
weight gain
Sexual dysfunction
Endocrine Dysturbances

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14
Q

What are the second generation antipsychotics?

A

Clozapine (Clozaril)
Risperidone (Risperidal)

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15
Q

What are the pharmacokinetics of second generation antipsychotics?

A

Serotonin and Dopamine receptor antagonists

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16
Q

What symptoms of schizophrenia do second generation antipsychotics treat?

A

Both positive and negative symptoms

17
Q

What are the advantages of FGAs and what are the advantages of SGAS?

A

FGAs: Cheap
SGAs: Minimal to no extrapyramindal symptoms or tardive dyskinesia

18
Q

What are the disadvantages to SGAs?

A

Tendency to cause significant weight gain, diabetes mellitus, dyslipidemia, and risk of metabolic syndrome

19
Q

What are the “third generation” antipsychotics?

A

Technically a subset of the SGAs, theyinclude Ariprpraxole (Abilify)
Brexpiprazole (Rexulti)
Cariprazine (Vraylar)

20
Q

What are the pharmacokinetics of TGAs?

A

Dopamine system stabilizers

21
Q

What are the benefits to TGAS?

A

May improve both positive and negative symptoms as well as congnitive function with little risk of EPS or Tardive Dyskinesia

22
Q

What are some of the general potentially dangerous effects of of Antipsychotics?

A

ACh toxicity (Antidote is Physotigmine)
Neuroleptic malignant syndrome
Agranulocytosis (Monitor ANC)
QT interval prolongation (EKG before starting med)
Liver impairment

23
Q

What is Benztropine?

A

An anticholinergic that is used to counteract Dystonia (An EP side effect that involves spasms of the muscles of the tongue, facem neck, back and upper eyes) normally caused by FGAs that is administered IV/IM

24
Q

What is diphenhydramine used for in regards to schizophrenia treatment?

A

It is used to treat psuedoparkinsonism (EP side effect involving bradykinesia, masked facem rigidity, shuffle, drooping and cogwheeling) that effects 15-36% of FGA patients, more often in women

*Knowledge connection: Why would this be involved in FGA symptom treatment?

25
Q

What are the agents use to reverse or manage antipsychotic medication side effects:
Dysonia:
Akathasia:
Psuedoparkinsonsim:
Tardive Dyskinesia:

A

Dysonia: Benztropine/cogentin
Akathasia: Benzodiazepines, beta blockers, anticholinergics
Psuedoparkinsonsim: Cognetin or Benadryl (diphenhydramine)
Tardive Dyskinesia: Discontinue anticholinergic and give benzodiazepines and switch to SGA

26
Q
A

Nurs 729 Psych Nursing (2 decks)

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