TEST 1 Part 1 Flashcards
Contact Dermatitis
Irritant- dryness, fissures, erythema, (Quick Rash)
Allergic - well demarcated (hours to days after) *pruritic
Topical Corticosteroids.
Atopic Dermatitis
Chronic relapsing eczema associated with pruritis
Antihistamines, Topical steroids, Emollients, phototherapy,
excoriation, lichenification
Adults: flexor extensors, neck eyes, wrists
Children: Extensors, cheeks
Eczema
A polymorphic inflammatory rxn pattern involving the epidermis and dermis (Pruritic!).
Types: acute, subacute, chronic
antihistamines, steroids
Acute: erythema, edema, vesiculation (weeping/oozing)
Subacute:
erythema, scaling, indistinct borders
Chronic: scaling, lichenified, hypo/hyper pigmented
Dyshidrosis
TAPIOCA VESSICLES
Sudden eruption of highly pruritic symmetrical vesicles of palms and soles
Topical steroids, Antihistamines,
Lichen Simplex Chronicus
plaques.
Occurs 2/2 habitual rubbing/scratching
stress
Steroids
Drug Eruptions
Beta lactams, aspirin, NSAIDS, sulfa drugs are most common.
Discontinue the drug
Dermatologic eruptions (M/C)- urticaria, ACD, EM-like eruptions, erythema nodosum.
Pulmonary- asthma, pneumonitis
Renal- interstitial nephritis, nephrotic syndrome.
Hematologic- thrombocytopenia, hemolytic anemia, eosinophilia, agranulocytosis.
Lichen Planus
inflammation reaction
5 P’s: pruritic, purple, papules, polygonal, planar.
“Wickham’s Striae”-white lacey lines
Antihistamines, topical/IL steroids, Acitretin, cyclosporine
Pityriasus Rosea
Asymptomatic distinctive skin eruption common on trunk and proximal extremities,
May be viral
Re oval plaque (herald patch) and then 1 week later Christmas tree pattern.
Treat symptomatically
will go away in 2-3 months
Psoriasis
Chronic immune mediated, inflammatory rxn. overactive Tcells
GABHS
Silver scale (micaceous),
Koebner’s (plaque),
Auspitz sign (pinpoint bleeding),
oil spot (nails)
Topical steroids, Vitamin D, Tar compounds, Phototherapy, systemic agents
Erythema Multiforme
target shaped skin lesions
Thought to be a cytotoxic ummune response to foreign viral or drug antigens.
affects palms and soles, and extensor forearms, symmetrical.bilateral, lesions may resolve in 1-2 wks, oral lesions, uticarial plaques
Steroids (oral), antivirals (HSV),
Stevens-johnson Syndrome
Severe blistering mucocutaneous syndrome (involves at least 2 mucous memranes). Causes: M. pneumonia, drugs, immunosuppresion
Flu-like symptoms. Erythematous papules, dusky appearing, target lesions,burning,
Nikolskys sign (can slide skin across and blister advances).
D/C offending drugs, supportive (hydration, infection, pain control, steroids, IVIG
Toxic Epidermal Necrolysis
widespread blistering and sloughing of the skin and mucous membranes.
Keratinocytic apoptosis.
Generalized pain with rash. Fever, malaise, anthralgia, leukopenia,thrombocytopenia, anema, urinary ret,
bullae with sloughing, + Nikolskys sign.
Labs: Biopsy (jelly roll)- full thickness epidermal split vs. superficial split
D/C offending agent, supportive
Scalded skin Syndrome
exfoliation of the skin in response to S. Aureus bacteria toxins
Macular erythema of the skin
gram stain and microscopic analysis of the infected tissues. PCR can be used for rapid diagnosis of S. Aurues infections.
PO antibiotics (penicillin, cephalosporin,
Bullous Pemphigoid
An autoimmune disorder with sub epidermal blisters with a high presence of perivascular, eosinophil (White blood cells) rich skin.
Male> female
>60 yo
M/C lesions are seen in the lower abdomen, groin, and flexor surfaces of the body
TOC is systemic glucosteroids.
Diagnosis can be made by a biopsy and direct immunofluorescence examination
Acne Vulgaris
Inflammation of pilosebaceous unites in certain areas of body
P.Acnes
Types: comedonal, nodulocystic, papulopustular
Antibacterial Soaps, Cleansers (SA and BPO), retinoids (topical/oral), antibiotics (topical/oral)-, COMBO most effective
