Test 1- Pain Pathway and Nerve Shit Flashcards
Which receptor does Substance P activate?
NK-1
Where does the first order neuron originate, and where does it synapse?
Originates: peripheral tissue
Synapses: dorsal horn of spinal cord
Which cranial nerves carry the pain fibers originating in the head, and where do they synapse with the second order neuron?
CN V- trigeminal CN VII- facial CN IX- glossopharyngeal CN X- Vagus All synapse with the 2nd order neuron in the brainstem (not the dorsal horn of the spinal cord)
How many lamina are located within the spinal cord?
10
Where does the 2nd order neuron synapse with the 1st order neuron? With the 3rd?
1st- 2nd: Dorsal horn of spinal cord (or brainstem for CNs)
2nd- 3rd: Thalamus
Where does the 3rd order neuron synapse with the second order neuron and where does it terminate?
Synapse: Thalamus
Termination: Post central gyrus (somatosensory areas I & II, and superior wall of sylvian fissure)
Which nerve fibers are mylinated?
A and B
What are some of the characteristics of A fibers?
Fast. Acute pain.
Sharp, well-localized sensation.
Mylinated.
What are some characteristics of C fibers?
Slow. Chronic pain.
Poorly localized sensation.
Unmylinated.
*Most numberous
Into which lamina do A delta fibers synapse?
Lamina I or V
Into which lamina do C fibers synapse?
Lamina II or III
Where is the substantia gelatinosa located?
Lamina II of the dorsal horn
To which receptors does Glutamate bind?
AMPA, NMDA, Kainate
True or Flase:
Most nociception results in pain
FALSE:
Most nociception does NOT result in pain, only in autonomic nervous system changes
How does Capsaicin work?
It prolongs the inhibition of C fibers by interacting with TRPV1 (transient receptor potential Vanilloid 1)
