Test 1 Drugs Flashcards
Which drug is an antiarrhythmic and is an inducer to 2C9 and 2D6?
Amiodarone
Which drug is a weak anethetic, blocks NMDA, and is involved with ligand gated ion channels?
Nitrous oxide
Which drug is a protectant for duodenal ulcers by reacting with HCl to inactivate it and protect ulcers from acid?
Sucralfate
Which drug is an antibiotic, blocks the 30S subunit of microbial ribosomes, thereby block protein synthesis?
Tetracycline
Which drug is used for treatment for poisoning/overdoses by binds to toxin/interrupts circulation, thereby stopping GI absorption?
Activated Charcole
What types of reactions does Naloxone do?
Carbonyl reduction
Which drug does Dealkylation reactions in cytochrome P450-dependent oxidations, and is also a substrate for 2D6?
Morphine
Which drug is a diuretic and HTN med that is a competitive antagonist of aldosterone and hass anti-androgenic effects?
Spironolactone
Which positive inotropic drug is used for respiratory diseases of COPD/asthma, narrow TI, competitive phosphodiesterase inhibitor, and is a adenosine receptor antagonist?
Theophylline
Which p450 enzyme is Nifedipine a substrate for?
3A4
Which p450 enzyme is Nortriptyline
a substrate for?
2D6
Which p450 enzyme is St John’s Wort
an inducer for?
3A4
What types of reactions is Diazepam involved with?
Glucuronidation conjunction
What types of P450 enzymes does Fe block?
ALL OF THEM. it binds to the active site and acts as a competitive inhbitor
Which drug has interactions wtih cisapride and is a substrate and inhbitor for 3A4?
Erythromycin
Which drug has a very toxic metabolite and is a substrate for 2E1?
Acetaminophen
Which drug is Used to treat acetaminophen OD’s by binding the toxic metabolites and spares the liver from dmg and also breaks disulfide bonds in mucus and makes it easier to cough up?
N-acetylcysteine
Which drug does acetylation conjunction reactions as well as is used as an inducer for 2E1?
Isonazid
Which P450 enzyme is Tamoxifen a substrate for?
2C9
The quinolone Ciprofloxacin is an inhibitor to which P450 enzyme?
1A2
Fluoxetine is an inhibitor to which 2 p450 enzymes?
2C19, 2D6
Which pain medication is used as an agonist for the mu opioid receptor/.
meperidine
Which Ca Channel blocker is a substrate and inhbitor for the 3A4 enzyme?
Verapamil
Which Anti-migrane drug is a partial agonist for the serotonin (5-HT) receptors, thereby dampening the effects vasodilation by activating these channels, which vasoconstrict the blood vessels in the brain?
Methysergide
Which antipsychotic has an incomplete oral bioavailability of 40% to 50% (due to extensive first pass metabolization in the liver)?
Fluphenazine
Which drug irreversibly acetylates cyclo-oxygenase and is involved with ester hydrolysis reactions?
Aspirin
What types of reactions is Digoxin involved with?
Glucaronidation reactions
Metropolol is a beta-antagonist which us a substrate for which P450 enzyme?
2D6
