Test 1 Drugs

Question 1

Which drug is an antiarrhythmic and is an inducer to 2C9 and 2D6?

Answer 1

Amiodarone

Question 2

Which drug is a weak anethetic, blocks NMDA, and is involved with ligand gated ion channels?

Answer 2

Nitrous oxide

Question 3

Which drug is a protectant for duodenal ulcers by reacting with HCl to inactivate it and protect ulcers from acid?

Answer 3

Sucralfate

Question 4

Which drug is an antibiotic, blocks the 30S subunit of microbial ribosomes, thereby block protein synthesis?

Answer 4

Tetracycline

Question 5

Which drug is used for treatment for poisoning/overdoses by binds to toxin/interrupts circulation, thereby stopping GI absorption?

Answer 5

Activated Charcole

Question 6

What types of reactions does Naloxone do?

Answer 6

Carbonyl reduction

Question 7

Which drug does Dealkylation reactions in cytochrome P450-dependent oxidations, and is also a substrate for 2D6?

Answer 7

Morphine

Question 8

Which drug is a diuretic and HTN med that is a competitive antagonist of aldosterone and hass anti-androgenic effects?

Answer 8

Spironolactone

Question 9

Which positive inotropic drug is used for respiratory diseases of COPD/asthma, narrow TI, competitive phosphodiesterase inhibitor, and is a adenosine receptor antagonist?

Answer 9

Theophylline

Question 10

Which p450 enzyme is Nifedipine a substrate for?

Answer 10

3A4

Question 11

Which p450 enzyme is Nortriptyline

a substrate for?

Answer 11

2D6

Question 12

Which p450 enzyme is St John’s Wort

an inducer for?

Answer 12

3A4

Question 13

What types of reactions is Diazepam involved with?

Answer 13

Glucuronidation conjunction

Question 14

What types of P450 enzymes does Fe block?

Answer 14

ALL OF THEM. it binds to the active site and acts as a competitive inhbitor

Question 15

Which drug has interactions wtih cisapride and is a substrate and inhbitor for 3A4?

Answer 15

Erythromycin

Question 16

Which drug has a very toxic metabolite and is a substrate for 2E1?

Answer 16

Acetaminophen

Question 17

Which drug is Used to treat acetaminophen OD’s by binding the toxic metabolites and spares the liver from dmg and also breaks disulfide bonds in mucus and makes it easier to cough up?

Answer 17

N-acetylcysteine

Question 18

Which drug does acetylation conjunction reactions as well as is used as an inducer for 2E1?

Answer 18

Isonazid

Question 19

Which P450 enzyme is Tamoxifen a substrate for?

Answer 19

2C9

Question 20

The quinolone Ciprofloxacin is an inhibitor to which P450 enzyme?

Answer 20

1A2

Question 21

Fluoxetine is an inhibitor to which 2 p450 enzymes?

Answer 21

2C19, 2D6

Question 22

Which pain medication is used as an agonist for the mu opioid receptor/.

Answer 22

meperidine

Question 23

Which Ca Channel blocker is a substrate and inhbitor for the 3A4 enzyme?

Answer 23

Verapamil

Question 24

Which Anti-migrane drug is a partial agonist for the serotonin (5-HT) receptors, thereby dampening the effects vasodilation by activating these channels, which vasoconstrict the blood vessels in the brain?

Answer 24

Methysergide

Question 25

Which antipsychotic has an incomplete oral bioavailability of 40% to 50% (due to extensive first pass metabolization in the liver)?

Answer 25

Fluphenazine

Question 26

Which drug irreversibly acetylates cyclo-oxygenase and is involved with ester hydrolysis reactions?

Answer 26

Aspirin

Question 27

What types of reactions is Digoxin involved with?

Answer 27

Glucaronidation reactions

Question 28

Metropolol is a beta-antagonist which us a substrate for which P450 enzyme?

Answer 28

2D6