Test 1 additions

Question 1

What is the significance of tylosis?

Answer 1

RHBDF2 mutation

increased risk for SCC

Question 2

What are the inheritance patterns for SPINK1 and PRSS1 mutations, respectively?

Answer 2

SPINK1 = Autosomal recessive

PRSS1 = autosomal dominant

Question 3

Where does angiodysplasia typically manifest?

Answer 3

Right colon

Question 4

What is the inheritance pattern of IPEX?

Answer 4

X linked

Question 5

What is the inheritance pattern of congenital lactase deficiency?

Answer 5

Autosomal recessive

Question 6

What is the inheritance pattern of abetalipoproteinemia and what stain is used to dx it?

Answer 6

Autosomal recessive

Oil red O stain for lipids

Question 7

Btw what two muscles does a zenker’s diverticulum typically occur?

Answer 7

inferior constrictor m and cricopharygeous m

Question 8

What is a phrygian cap?

Answer 8

congenital abnormality where the fundus of the gallbladder is folded inward

Question 9

What are hutchison teeth?

Answer 9

vampire teeth due to congenital syphillis

Question 10

What stain is used in a tzanck smear and what are you looking for?

Answer 10

wright or giemsa stain

+ if acantholytic keratinocytes or multinucleated acantholytic keratinocytes are detected

(this is for HSV)

Question 11

What is the order of mutations in HpV caused SCC?

Answer 11

p16 –> TP53 –> cyclin D

Question 12

What is the duct associated w/ the parotid gland?

Answer 12

stensen’s duct

Question 13

What enzymes do the parotid gland and submucosa of the tongue produce?

Answer 13

parotid: salivary amylase

submucosa of tongue: lingual lipase

Question 14

What mutations are associated w/ mucoepidermoid carcinoma?

Answer 14

(11:19)(q21;p13) –> MECT1-MAML2 fusion gene

Question 15

What foramen does the facial nerve exit when it is close to the parotid gland?

Answer 15

stylomastoid foramen

Question 16

Where is meckels diverticulum located typically?

Answer 16

RLQ on anti-mesenteric side

Question 17

What antibodies will be positive in diffuse scleroderma?

limited scleroderma?

Answer 17

diffuse: anti-topoisomerase/Anti-Scl-70
limited: anti-centromere Abs

Question 18

What type of cancer are ppl with sjogren’s syndrome more likely to get?

Answer 18

B cell non-Hodgkin lymphoma

Question 19

What artery would be damaged in a posterior stomach body perforation?

Answer 19

splenic A

Question 20

What lesion is a complication of chronic otitis media?

Answer 20

cholesteatoma

Question 21

What lesion is often seen in young ppl around an erupting tooth?

Answer 21

dentigerous cyst

Question 22

What distinguishes a branchial cyst from a thyroglossal duct cyst?

Answer 22

branchial = more lateral, don’t have thyroid tissue, and have a lot of lymphoid tissue

thyroglossal = midline, just adjacent to hyoid bone; squamous, respiratory epithelium, thyroid follicles, surrounded by fibrous tissue and lymphoid follicles

Question 23

What genetics are associated with diffuse gastric carcinoma?

Answer 23

CDH1 loss of function mutation –> can inflitrate as single cells

mucin

Question 24

What cancer is most associated with celiac dz?

Answer 24

T-cell lymphoma

Question 25

What is positive fecal calprotectin linked to?

Answer 25

IBD

Question 26

What is tea colored urine associated with?

Answer 26

cholecystitis

Question 27

What antibody do you check to evaluate for celiac dz in someone who is IgA deficient?

Answer 27

anti-DGP

Question 28

What would you see on EGD in whipple dz?

Answer 28

shaggy looking villi full of bacilli-laden macrophage