Test 1 Flashcards
4 Phases
PA, Induction, Maintenance, Recovery
Why do we use PA drugs?
Sedative/tranquilize, pre-emptive analgesia, Prevent bradycardia, decrease amount of gases
When do you give PA’s?
15-30 minutes prior to induction
5 PA classifications
Anticholinergics, tranquilizers, alpha-2 agonists (sedatives), Opioids (narcotics), Neuroleptanalgesia
Anticholinergic Drugs
Atropine, Glycopyrrolate
Autonomic Nervous System branches
Sympathetic and Parasympathetic
Epinephrine
(fight or flight) Increases HR, BP, RR
Bronchial dilation, decreases GI motility, Mydriasis, Increases blood glucose
Sympathetic NS
Vagus nerve
Runs to eyes, pharynx, larynx, trachea, lungs, heart, GI tract
Parasympathetic NS
Acetylcholine
Routine body functions: decrease HR, BP, RR. Bronchial constriction, Increases GI motility, Miosis
Anticholinergics block:
Acetylcholine and the vagal nerve
SLURED <3
Decrease salivery Decrease Lacrimal Contracts the urinary bladder Causes bronchodilation Causes mydriasis Decreases digestion Blocks bradycardia
Main reason for using an anticholinergic
Prevent Bradycardia, +/- dry secretion
Tx of bradycardia and AV blocks
Atropine
Antidote for organophosphate (insecticide) poisoning
Atropine
Atropine duration
60-90 minutes
Glycopyrrolate duration
4 hours
Tranquilizer groups
Phenothiazines, Benzodiazepines
Why we use a Tranquilizer as a PA
Relaxation and calming
Do Tranq. have analgesia?
NO, but can improve analgesic effects
Phenothiazines
Acepromazine/Acetylpromazine (Promace®)
Benzodiazepines
Diazepam (Valium®), Midazolam (Versed®), Zolezapam (in Telazol®)
Acepromazine (Promace®)
Water soluble, YELLOW
Ace duration
4-8-24hr up to 48hrs in geriatric, neonates or liver dz
Phenothiazines and Cats
Less pronounced effect
Effects on Phenothiazines
Calming, Antiemetic, Antiarrhythmic, Antihistamine, Vasodilation, no significant respiratory or cardiac depression, Prolapse of the 3rd eyelid, penile prolapse, MAY lower seizure threshold
Main effect for Phenothiazine
Vasodilation
Max dose of Acepromazine
3mg (IM, SQ), NO reversal
Benzodiazepine Group
Diazapam (Valium®), Midazolam (Versed®), Zolazepam (In Telazol®)
Reversal agent for Benzodiazepine tranq.
Flumazenil (a specific antagonist for benzo)