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Hematology Lecture > Test 1 > Flashcards

Test 1 Flashcards

1
Q

job is to envelop cell contents and give cell shape
semi permeable
made of phospholipid protein

A

cell membrane

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2
Q

control center

composed of DNA

A

nucleus

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3
Q

composed of RNA

rRNA synthesized processed

A

nucleoli

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4
Q

made of nucleic acids and protein

A

chromatin

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5
Q

chromatin that is dark staining, mature, inactive

A

heterochromatin

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6
Q

chromatin that is light staining, diffuse, immature, active

A

euchromatin

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7
Q

membrane that surrounds nucleus

A

nuclear envelope

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8
Q

system of stacked membranes

modifies and sorts and packages macromolecules for secretion

A

golgi body/complex

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9
Q

membrane lined tubules that go from nucleus to membrane

where proteins are stored and transported

A

ER

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10
Q

composed of rRNA and where proteins are synthesized

A

ribosomes

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11
Q

granules

membrane bound sacs that contain digestive enzymes

A

lysosomes

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12
Q

made of actin and myosin

provide support and assist in cell division

A

microfilaments

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13
Q

maintain cell shape

play a role in motility and mitosis

A

microtubules

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14
Q

play a role in mitosis
made of microtubules
only evident when cell is mitotic

A

centriole

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15
Q

hematopoiesis in the yolk sac

A

primitive hematopoiesis

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16
Q

hematopoiesis in the hepatic and medullary

A

definitive hematopoiesis

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17
Q

vein in bone marrow where mature cells will leave to go to peripheral blood

A

central sinus

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18
Q

areas in bone marrow that contain developing cells

A

hematopoietic cords

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19
Q

supply blood to bone marrow

A

central artery

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20
Q

network of supporting tissues for BM

made of macrophages, fibroblasts, adipocyes

A

stroma

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21
Q

cells that hold the cords together and regulate flow

A

endothelial cells

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22
Q

part of stroma, type of stem cells for other cells that aren’t blood cells

A

fibroblast

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23
Q

macrophage surrounded by developing RBCs

A

erythroblastic island

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24
Q

in spleen, old or damaged RBCs are removed by macs

A

culling

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25
Q

in spleen, pluck out particles from RBC without destroying them

A

pitting

26
Q

cells that can become any of specialized cells

A

pluripotent stem cell, hematopoietic stem cell

27
Q

committed to a cell line

A

multipotent (unipotential)

28
Q

precursors of a myeloid or lymphoid

A

progenitor cells

29
Q

cells divide and multiply by mitotic divisions

A

proliferation

30
Q

when cell differentiates from progenitor to mature

A

differentiation

31
Q

cell death initiated by cell itself

A

apoptosis

32
Q

glycoproteins that have a direct effect on hematopoiesis

A

growth factors, cytokines

33
Q

production of WBCs

A

leukopoiesis

34
Q

cells that contain granules in cytoplasm

A

granulocytes

35
Q

not segmented and do not have granules

A

mononuclear cells

36
Q

found very early in maturation
non-specific, azurophilic
contain myeloperoxidase, muramidase, defense’s
dark purple

A

primary granules

37
Q

found in more mature cells
may be red, red/orange, blue, pink
contain lysozyme, collagenase, alkaline phosphatase, lactoferrin, plasminogen activators, heparin

A

secondary granules

38
Q

found in neutrophils

pink/violet color

A

tertiary granules

39
Q

part of cell death where nucleus becomes condensed, refractile

A

pyknosis

40
Q

part of cell death where nuclei break up into fragments

A

karyorrhexis

41
Q

part of cell death where nuclei are dissolved

A

karyolylsis

42
Q

pool that contains stem and progenitor cells

A

mitotic pool

43
Q

pool where maturation and proliferation occurs

A

storage pool

44
Q

pool that consists of cells actually circulating in blood and can be counted

A

circulating pool

45
Q

pool where WBC is attached to vessel walls

A

marginating pool

46
Q

when neutrophil adheres to vein/vessel and penetrates through endothelia cell junctions into tissue

A

diapedesis

47
Q

to prepare for dining, complement coats in or immunoglobulins

A

opsonization

48
Q

when bacteria is inside of neutrophil within a vacuole

A

phagosome

49
Q

total WBC count greater than 11,000

A

leukocytosis

50
Q

increased WBC count not from a disease

A

pseudoleukocytosis

51
Q

excessive leukocyte response to infection, inflammation, or neoplasm

A

leukemoid reaction

52
Q

increase in WBC count with increase in immature RBCs

A

leukoerythroblastic reaction

53
Q

decrease in WBC count less than 4000

A

leukopenia

54
Q

neutrophil with greater than 5 lobes

A

hypersegmentation

55
Q

bi lobed nucleus found by accident, autosomal dominant

A

pelger huet anomaly

56
Q

underlying condition causing bi lobed nucleus

A

pseudo pelter huet anomaly

57
Q

caused by bacterial infections, inflammation

granules become more numerous, larger, and darker staining

A

toxic granulation

58
Q

single or multiple grey/blue inclusions near edge of cell made of rough ER

A

Dohle body

59
Q

autosomal disorder of having dole like body inclusions in cytoplasm and also see giant platelets

A

may hegglin anomaly

60
Q

large purplish granules, coarse, azurophilic, autosomal recessive
skeletal abnormalities, facial abnormalities

A

alder reilly anomaly

61
Q

rare autosomal recessive disorder characterized by giant lysosomal granules with abnormal membrane granule fusion, lethal

A

chediak higashi syndrome

62
Q

antibodies against sheep RBCs

A

heterophile antibodies

Hematology Lecture (3 decks)

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