Terms and Knowledge Flashcards
Extracellular fluid is ____ of total body water
1/3
Intracellular fluid is ______ of total body water
2/3
ECF contains these three divisions
Interstitial
Intravascular
Transcellular
Compounds that separate into ions when they are dissolved into water
Electrolytes
Needed to maintain and/or regulate fluid balance, nerve impulse transmission, acid-base balance, and cellular chemical reactions.
Sodium (Na2+)
Normal sodium level:
136-145 mEq/L
Necessary for glycogen deposits in the liver and skeletal muscle, transmission, and conduction of nerve impulses, cardiac conduction, and smooth and skeletal contraction. (Maintains resting potential of skeletal, smooth, and cardiac muscle allowing for normal function)
Potassium (K+)
Normal potassium range:
3.5 - 5.0 mEq/L
Necessary for bone and tooth formation, blood clotting, hormone secretion, cell membrane integrity, cardiac conduction, transmission of nerve impulses, and muscle contraction. (Influences excitability of nerve and muscle cells, necessary for muscle contraction)
Calcium (Ca2+)
Essential for enzyme activities (cofactor for enzymes), neurochemical activities, and cardiac and skeletal excitability. About 50- 60% is found in the bone.
Magnesium (Mg2+)
The major anion in ECF, always follows sodium, and is regulated through dietary intake and kidneys.
Chloride (Cl-)
Major chemical base buffer in body, found in ECF and ICF, and regulated by the kidneys
Bicarbonate (HCO3-)
Normal HCO3- (Bicarbonate) Levels:
22- 26 mEq/L
Found in ICF with a small amount in ECF, assists in acid-base balance, helps in addition to calcium to develop and maintain bones and teeth, and is inversely proportional to calcium (one rises, other falls)
(Necessary for production of ATP)
Phosphorus/Phosphate (PO4)
Normal CO2 Levels:
22- 30 mEq/L
Normal ABG pH:
7.35- 7.45
Normal PaCO2 level:
35- 45 mm Hg
Normal PaO2 level:
80- 100 mm Hg
Normal O2 Sat.
95- 100%
The liquid portion of the blood (plasma)
Intravascular fluid
Located between the cells and outside the blood vessels
Interstitial fluid
Cerebrospinal fluid, pleural fluid, peritoneal fluid, and synovial fluids that are secreted by epithelial cells.
Transcellular fluids
Mineral salts contained in the fluid of the body compartments.
Electrolytes
Balance: Cations= Anions
Cations and Anions combine to make ______.
Salts
A measure of the number of particles per kilogram of water.
Osmolality
A fluid with the same concentration of nonpermeant particles as normal blood.
Isotonic solution (Normal saline)
A solution more dilute than blood
Hypotonic solution (Sodium Chloride containing- 0.45%)
A solution more concentrated than normal blood.
Hypertonic Solution (containing sodium chloride- 3%)
Concentrations of Na+, Cl-, and HCO3- are higher in the ________.
ECF
Concentrations of K+, Mg2+, and PO43- are higher in the _______.
ICF
Four processes that move water and electrolytes between body compartments to maintain equal osmolality.
Active Transport
Diffusion
Osmosis
Filtration
Movement of ions against osmotic pressure to an area of higher pressure, requires energy
Active Transport
Passive movement of electrolytes or other particles down the concentration gradient, Higher to lower concentrations. Fluids and Ions move
Diffusion
Movement of water (or other solute) from an area of less to one of greater concentration (low- high). Only fluids move
Osmosis
Movement across a membrane, under pressure, from higher to lower pressure
Filtration
Total fluid balance (Homeostasis) involves:
Fluid intake and absorption
Fluid distribution
Fluid output
An inward-pulling force that is caused by particles in the fluid- Greater at venous end
osmotic pressure
The force of the fluid pressing outward against a surface- Greater at arterial end
hydrostatic pressure
Albumin and other proteins contained in blood; much larger than electrolytes, glucose, and other molecules that dissolve easily.
Colloids
An inward-pulling force caused by blood proteins that helps move fluids.
Oncotic pressure (colloid osmotic pressure)
Sources of fluid intake:
Eating (absorption)
Drinking (Includes ice cream, ice chips, and jello)
IV
Rectal enema
Irrigation (of body cavities able to absorb fluids)
Fluid intake regulation:
Thirst (hypothalamus)
Habit
Social reasons
Patients at risk for dehydration related to thirst:
Infants
Neurological/psychological problems
Older adults
(Those unable to perceive or communicate thirst)
Movement of fluid among its various compartments
Fluid Distribution
Fluid intake range:
2200- 2700 mL
Fluid output range: Total
2200- 2700 mL
Fluid output range: Skin (insensible and sweat)
500- 600 mL
Fluid output range: Insensible (lungs)
400mL
Fluid output range: GI:
100- 200 mL
Fluid output range: Urine
1200- 1500 mL
Fluid output occurs in these four organs (Normal)
Skin, Lungs, GI, Kidneys
Abnormal routes of fluid output:
Vomiting
wound drainage
Hemorrhage
Fluid output that is not perceived, such as in the skin or the lungs.
Insensible (Burns, fever)
Approximately __ to ___ L of fluid moves into the GI tract daily then returns to the ECF.
3, 6
Angiotensin II does this:
releases aldosterone from adrenal cortex increases thirst causes vasoconstriction (increases BP)
Fluid output is affected by these hormones:
ADH
Hormones in the RAAS (Angiotensin system)
ANP
_____ regulates the Osmolality of the body fluids by influencing how much water is excreted in the urine.
ADH (antidiuretic hormone)
Factors that increase ADH:
Severely decreased blood volume Dehydration Hemorrhage Pain Stressors Medications
Factors that increase RAAS activity:
Hemorrhage
Vomiting
Influences how much sodium and water are excreted n the urine.
RAAS
Insufficient isotonic fluid in the extracellular compartment
ECV deficit
Decreased vascular volume
Hypovolemia
Occurs when there is too much isotonic fluid in the extracellular compartment.
ECV excess
An imbalance in which the body fluids become hypo or hyper tonic
Osmolality imbalance (Hyper or hypo natremia)
Water deficit, loss of relatively more water than salt, or gain of relatively more salt than water.
Hypernatremia
Water excess/water intoxication, gain of relatively more water than salt, or loss of relatively more salt than water
Hyponatremia
Clinical dehydration is a combination of _________ and ________.
ECV deficit and hypernatremia
Release of ADH causes:
Increase in volume
excreted from posterior pituitary—> kidney, H2O is returned to the blood, less H2O is excreted in the urine
Release of Aldosterone causes:
Increase in volume
Adrenal cortex—> Kidneys, Na+, Cl-, and H2O returned to the blood and K+ and H+ are excreted in the urine
Release of ANP causes:
Decrease in volume
Heart—-> kidneys, Na+, Cl-, and H2O are excreted in the urine
ECV volume excess: definition
Body fluids increased in volume, but normal tonicity
Hypernatremia: definition
Hypertonic (more salt than water)– Loss of relatively more water than salt OR gain of relatively more salt than water
Hyponatremia: Definition
Hypotonic (more water than salt)– Gain of relatively more water than salt OR loss of relatively more salt than water
Decreased vascular volume
Hypovolemia
Intake of Potassium (K+) (FOODS)
Fruits Potatoes Instant coffee Molasses Brazil Nuts
Intake of Calcium (Ca2+) (Foods)
Dairy Products
Canned fish with bones
Broccoli
Oranges
Intake of Magnesium (Mg2+) (Foods)
Dark green leafy vegetables
Whole grains
Mg2+ containing laxatives/Antacids
Phosphate (PO4) Intake (Foods)
Milk
Processed Foods
Maintains resting membrane potential of skeletal smooth and cardiac muscle allowing for normal muscle function
Potassium
Influences excitability of nerve and muscle cells and is necessary for muscle contraction
Calcium
Influences function of neuromuscular junctions and is a cofactor for numerous enzymes
Magnesium
Necessary for production of ATP (energy source for metabolism)
Phosphate
Which hormones are released when fluid volume is too low?
ADH, Aldosterone (RAAS)
Which hormones are released when fluid is in excess?
ANP
Electrolyte output occurs in:
Urine Feces Sweat Vomiting Drainage of tubes/fistulas -- Must increase intake --
Electrolyte excess occurs in:
Oliguria Endocrine disorders Medications Shift of electrolytes from bone into ECF -- Must decrease intake --
Hypokalmeia: definition
Abnormally low potassium concentration in the blood
Hyperkalemia: definition
Abnormally high potassium ion concentration in the blood
Hypocalcemia definition:
Abnormally low calcium concentration in the blood
hypercalcemia definition:
abnormally high calcium concentration in the blood
Hypomagnesemia definition:
Abnormally low magnesium concentration in the blood
Hypermagnemesia definition:
Abnormally high magnesium concentration in the blood
Three processes of acid-base balance:
Acid production
Acid buffering
Acid excretion
Laboratory tests of a sample of arterial blood
ABGs (Arterial blood gases)
major regulator of fluid output:
kidneys
Arises from alveolar hypoventilation
Respiratory Acidosis
Arises from alveolar hyperventilation
Respiratory Alkalosis
Occurs from an increase of metabolic acid or decrease in bicarbonate
Metabolic Acidosis
Occurs from a increase of bicarbonate or a decrease of metabolic acid
Metabolic Alkalosis
A pH of greater than 7.45 in an ABG
Alkalosis
A pH of less than 7.35 in an ABG
Acidosis
Blood administered faster than circulation can accommodate
Circulatory Overload
Bacterial contamination of transfused blood components
Sepsis
People with these two electrolyte imbalances need bowel management for constipation.
Hypokalemia, Hypercalcemia
When giving a blood transfusion, ensure you have an _______ from the provider, perform a thorough ________, include a patients ______ vital signs, ensure everything is checked by _____ nurses, and stay with the patient for the first _____ minutes of the transfusion
order, assessment, baseline, Two, 15
Collection and reinfusion of a patient’s own blood
Autologous transfusion
An immune response to transfused blood/blood components
Transfusion reaction s
Blood transfusions can be used for these 3 reasons:
- Increasing blood volume after surgery, trauma, or hemorrhage
- Increasing RBCs and maintaining hemoglobin levels (severe anemia)
- Providing selected cellular components in replacement therapy (clotting factors, platelets, albumin)
Signs of hematoma
bruising
Blood enters tissue at venipuncture site
Hematoma
Signs of Phlebitis
Redness, Inflammation, Heat, Tenderness
*along the course of the vein and can cause thrombophlebitis (blood clots)
Inflammation of the vein resulting from chemical, mechanical or bacterial causes
Phelebitis
Signs and symptoms: Extravasation/Infiltration
Coolness, paleness, swelling
IV fluid that contains additives enters subcutaneous tissue and cause damage
Extravasation
When an IV catheter becomes dislodged or a vein ruptures and IV fluids enter subcutaneous tissue
Infiltration
A technique in which a vein is punctured through the skin by a sharp rigid stylet
Venipuncture
CRBSI
Catheter related bloodstream infection
Enter through a peripheral arm vein and extend through the venous system to the superior vena cava where they terminate.
PICC (Peripherally inserted central catheters)
central lines more effective for large volumes of fluid
Catheters or infusion ports designed for repeated access to the vascular system.
VADs (Vascular access devices)
Never administer ____ additive IV solution via IV push
KCl (Potassium containing)
These solutions have a greater osmolality than body fluids and have higher sodium concentrations; they increase osmolality rapidly and pull water out of cells
Hypertonic
These solutions have an osmolality less than body fluids, causing dilution of the body fluid and moving water into cells
Hypotonic Solutions
A low osmolality fluid is administered through a _________ catheter.
Peripheral
A high osmolality fluid is administered through a _______ catheter
Central
Parenteral replacement includes:
PN (parenteral nutrition)
IV fluids
Electrolyte therapy (Crystalloids)
Blood/blood component administration (colloids)