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PMC112 - 2nd Sem/1st Cycle > [TERM2:L2]: Transdermal Drug Delivery Systems and Technologies > Flashcards

[TERM2:L2]: Transdermal Drug Delivery Systems and Technologies Flashcards

1
Q

Absorption of substances from outside the skin to positions beneath the skin, including entrance into the bloodstream.

A

Percutaneous Absorption

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2
Q

the drug incorporated in an appropriate vehicle must
interface the skin surface in sufficient concentration

A

Right Vehicle

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3
Q

as concentration of the drug substance in the
vehicle increases, the amount of drug percutaneously absorbed increases Factors Affecting Percutaneous Absorption

A

Drug Concentration

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4
Q

more is absorbed through the percutaneous absorption when the drug substance is applied to a larger surface area

A

Surface Area

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5
Q

the drug substance should have a greater physicochemical attraction to the skin than to the vehicle

A

Physicochemical Attraction

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6
Q

same degree of solubility of the drug both in oil and
water is essential for effective percutaneous absorption Factors Affecting Percutaneous Absorption

A

Degree of Solubility

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7
Q

drug absorption appears to be enhanced from vehicles
that easily cover the skin surface, mix readily with the sebum and bring the
drug into contact with the tissue cells for absorption

A

Nature of Vehicle

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8
Q

vehicle that increase the amount of moisture
imbibed by the skin generally favor the percutaneous absorption of the
drug

A

Moisturizing Vehicle

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9
Q

this appears to increase the rate of passage of all
substances that penetrate the skin Factors Affecting Percutaneous Absorption

A

Skin hydration

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10
Q

hydration of the skin is influenced not only by the type of vehicle but also by the absence or presence of a bandage over the medicated application. Occlusive bandage is more effective

A

Bandage

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11
Q

The amount of rubbing in or inunctions of the topical
application will have a bearing on the amount of drug absorbed Factors Affecting Percutaneous Absorption

A

Skin stimulation

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12
Q

thin horny layer absorption has greater percutaneous
absorption of the drug

A

Horny Layer

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13
Q

period of time the medicated application is permitted to remain in contact with the skin. The longer the period of time, the greater is
the absorption

A

Length of Time

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14
Q

Factors Affecting Percutaneous Absorption

A
  1. Right Vehicle
  2. Drug Concentration
  3. Surface Area
  4. Physicochemical Attraction
  5. Degree of Solubility
  6. Nature of Vehicle
  7. Moisturizing Vehicle
  8. Skin hydration
  9. Bandage
  10. Skin stimulation
  11. Horny Layer
  12. Length of Time
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15
Q

a film of emulsified material composed of a
complex mixture of sebum, sweat and
desquamating horny layer.

A

Skin

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16
Q

a layer of dead epidermal cells, situated directly beneath the emulsified film.

A

HORNY LAYER OR STRATUM CORNEUM

17
Q

a 10- to 15-millimicron thick layer of flat partially desiccated, non-living tissue
which forms the skin’s outermost surface. * The percutaneous absorption of a drug generally results from the direct penetration of the drug through this layer.

A

HORNY LAYER OR STRATUM CORNEUM

18
Q

Being keratinized tissues, it behaves as a semi-permeable artificial membrane and drug molecules penetrate by passive diffusion.

A

HORNY LAYER OR STRATUM CORNEUM

19
Q

The lipid component of this tissue is considered the
factor directly responsible for low penetration of drugs

A

HORNY LAYER OR STRATUM CORNEUM

20
Q

Located beneath the horny layer

If the skin is intact, the main site for the penetration of a drug is
through this tissue

A

BARRIER LAYER OR LIVING EPIDERMIS OR STRATUM
GERMINATIVUM

21
Q

When the drug reaches the vascularized dermal layers, it becomes available for absorption into the general circulation

A

DERMIS OR TRUE SKIN

22
Q

Histological Divisions of Skin

A
  1. HORNY LAYER OR STRATUM CORNEUM
  2. BARRIER LAYER OR LIVING EPIDERMIS OR STRATUM
    GERMINATIVUM
  3. DERMIS OR TRUE SKIN
23
Q

rise from the subcutaneous fat tissue into the dermis up to the epidermis

A

BLOOD CAPILLARIES AND NERVE FIBERS

24
Q

present in the subcutaneous tissue yield their products by way of sweat ducts which find their way to the surface of the skin

A

SWEAT GLANDS

25
Q

originating in the dermis and subcutaneous layers also find their way to the surface and are revealed as ducts and hairs respectively

A

SEBACEOUS (OIL) GLANDS AND HAIR FOLLICLES

26
Q

Other Parts of the Skin

A
  1. BLOOD CAPILLARIES AND NERVE FIBERS
  2. SWEAT GLANDS
  3. SEBACEOUS (OIL) GLANDS AND HAIR FOLLICLES
27
Q

Through the walls of the hair follicles

Through the sweat glands or sebaceous
glands

Between the cells of the horny layer

A

Penetration of Drugs Through the
Skin

28
Q

Permeation across the cells

A

Transcellular penetration

29
Q

Permeation between the cells

A

Intercellular penetration

30
Q

Permeation via hair follicles, sweat and sebum glands and pilosebaceous apparatus

A

Folicular penetration

31
Q

Permeation of the Skin Occur by Diffusion via:

A
  1. Transcellular penetration
  2. Intercellular penetration
  3. Folicular penetration
32
Q

The rate of the drug movement across these skin layers is dependent on the _________________, its __________________ and its ____________________.

A

drug concentration

aqueous solubility

oil/water partition coefficient

33
Q

Substances that possess both aqueous and lipid solubility characteristics
are good candidates for __________ through ______ layer as well as through
__________ and __________ layers

A

diffusion

horny

epidermal and dermal

34
Q

usually present in dermatological preparations such as liquids, gels, ointments, creams or pastes depending not only upon the physicochemical properties of the medicinal substance but also upon its behavior when
placed in the pharmaceutical vehicle and upon the condition of the skin.

A

Percutaneous Absorption

35
Q

The vehicle influences the rate and degree of penetration of medicinal
agents and the degree and rate vary with different drugs and with different
vehicles

A

Percutaneous Absorption

PMC112 - 2nd Sem/1st Cycle (5 decks)

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