Teratogens/Maternal Dz Flashcards
1
Q
Thalidomide
A
- limb defects & ear malformation w deafness
2
Q
Carbamazepine
A
-Spina bifida
3
Q
Methrotrexate
A
- craniosynostosis, cranialfacial abnor, limb defects
4
Q
ACE inhibitors
A
-renal dysgenesis, oligohydramnios & skull ossification defects
5
Q
Diethylstilbestrol (DES)
A
-vaginal adenocarcinoma, male infertility
6
Q
Lithium
A
-Ebstain anomaly
7
Q
Phenytoin
A
- fetal hydantoin Sy:growth deficiency, MR, craniofacial abn, hypoplastic nails
- Vitamin K deficiency–> bleeding
8
Q
Retinoic acid
A
- similar to DiGeorge Sy, microcephaly, external auditory canal abnorma
9
Q
Streptomycin
A
- hearing loss
10
Q
Tetracycline
A
- bone & tooth staining
11
Q
Valproic acid
A
-spina bifida
12
Q
Warfarin
A
- fetal warfarin sy:nasal hypoplasia, stippled epiphyses
13
Q
MAternal DM
A
- sacral agenesis, situs abn, holoprosencephaly, congenital H Dz
14
Q
Maternal Hyperthermia- prolongued
A
-neural tube defects
15
Q
Maternal Parvovirus
A
-Congestive heart failure leading to hydrops & death
