Teratogens- Cole Flashcards

1
Q

what marks the time that fetuses are susceptibile to teratogens?

A

when implantation occurs

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2
Q

what is a malformation?

A

anomalie due to an intrinsic factor

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3
Q

what is a deformation?

A

anomalie due to extrinsic factor

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4
Q

what is the dongenital disease associated with cataracts, PDA, microcephaly?

A

congenital rubella

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5
Q

what is the most common fetal infection, characterized by microcephaly, microphthalmia, IUGR?

A

CMV

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6
Q

what is the infection characterized by microcephaly, retinal dysplasia, microphthalmia?

A

herpes

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7
Q

what is associated with limb hypoplasia and muscle atrophy?

A

VZV

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8
Q

what is the triad of toxoplasmosis?

A

hydrocephalus, calcification in the brain, and chorioretinitis

can also see, mental retardation, microcephaly

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9
Q

what are teh characteristcis of syphilis?

A

dental abnormalities, deafness, skin and bone lesions, mental retardation

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10
Q

what type fo problems usually result from fevers and high temperatures?

A

CNS related, cleft lip /palate

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11
Q

what can diazepam cause to fetus?

A

cleft lip and palate

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12
Q

what can streptomycin lead to ?

A

sensorineural deafness

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13
Q

what leads to hypoplastic nose, microcephaly, or hydrocephaly, , seizures…

A

warfarin syndrome

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14
Q

what can anticonvulsants ( valproic acid, diphenylhydantoin lead to?

A

neural tube defects

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15
Q

what is the culprit if you see decrease in oxygen, sodium, potassium, and number of platelets?

A

thiazide diuretics

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16
Q

wehat does thalidomide lead to?

A

phocomelia

17
Q

what can methotrxate, aminopterin, busulfan ( anti neoplastics) lead to?

A

microcephaly, cranisynostosis, micrognathia, low set ears, most die in utero or within first year of life

18
Q

what can accutane and rogaine lead to? ( retinoic acid?

A

trianglular face, craniofacial malformation, heart problems, retardation

19
Q

a mother that is adicted to heroin ( opiate) can do what to the child?

A

passes on the addiction to opiates to the baby, the baby will show signs of withdrawal

20
Q

what can tobaccoo lead to?

A

IUGR

21
Q

what are some signs of fetal meth?

A

shaking and tremors, cerebral injury, fits of rage, coordination problems, cerebral palsy is common

22
Q

what is the most common teratogen?

A

alcohol

23
Q

what are the features of a fetal alcohol syndrome baby?

A

short palpebral fissures, flat midface, thin upper lip, epicanthal folds

24
Q

what does DES exposure lead to ?

A

T shaped uterus, and increased chance of vaginal adenocarcinoma

25
Q

what aer the most common problems with diabetic mothers?

A

heart and neural tube defects

26
Q

what does obesity increase the chance of?

A

neural tube defects

27
Q

wat does hypoxia lead to?

A

cerebral palsy