Teratogens- Cole Flashcards
what marks the time that fetuses are susceptibile to teratogens?
when implantation occurs
what is a malformation?
anomalie due to an intrinsic factor
what is a deformation?
anomalie due to extrinsic factor
what is the dongenital disease associated with cataracts, PDA, microcephaly?
congenital rubella
what is the most common fetal infection, characterized by microcephaly, microphthalmia, IUGR?
CMV
what is the infection characterized by microcephaly, retinal dysplasia, microphthalmia?
herpes
what is associated with limb hypoplasia and muscle atrophy?
VZV
what is the triad of toxoplasmosis?
hydrocephalus, calcification in the brain, and chorioretinitis
can also see, mental retardation, microcephaly
what are teh characteristcis of syphilis?
dental abnormalities, deafness, skin and bone lesions, mental retardation
what type fo problems usually result from fevers and high temperatures?
CNS related, cleft lip /palate
what can diazepam cause to fetus?
cleft lip and palate
what can streptomycin lead to ?
sensorineural deafness
what leads to hypoplastic nose, microcephaly, or hydrocephaly, , seizures…
warfarin syndrome
what can anticonvulsants ( valproic acid, diphenylhydantoin lead to?
neural tube defects
what is the culprit if you see decrease in oxygen, sodium, potassium, and number of platelets?
thiazide diuretics
wehat does thalidomide lead to?
phocomelia
what can methotrxate, aminopterin, busulfan ( anti neoplastics) lead to?
microcephaly, cranisynostosis, micrognathia, low set ears, most die in utero or within first year of life
what can accutane and rogaine lead to? ( retinoic acid?
trianglular face, craniofacial malformation, heart problems, retardation
a mother that is adicted to heroin ( opiate) can do what to the child?
passes on the addiction to opiates to the baby, the baby will show signs of withdrawal
what can tobaccoo lead to?
IUGR
what are some signs of fetal meth?
shaking and tremors, cerebral injury, fits of rage, coordination problems, cerebral palsy is common
what is the most common teratogen?
alcohol
what are the features of a fetal alcohol syndrome baby?
short palpebral fissures, flat midface, thin upper lip, epicanthal folds
what does DES exposure lead to ?
T shaped uterus, and increased chance of vaginal adenocarcinoma
