Teratogenic Drugs/ COMMON TERATOGENS (ToRCH and other Factors)

Question 1

Masculinization of female infants

Answer 1

Androgen, estrogen, progesterone

Question 2

Phocomelia, cardiac and lung defect

Answer 2

Thalidomide

Question 3

Cleft lip and palate, congenital heart diseases

Answer 3

Anticonvulsant (Dilantin)

Question 4

Congenital Heart defects

Answer 4

Lithium

Question 5

Yellow staining of teeth, inhibit bone growth

Answer 5

Tetracycline

Question 6

hyperbilirubinemia

Answer 6

Vitamin K

Question 7

Neonatal bleeding, IUGR

Answer 7

Salicylates

Question 8

Fetal metabolic alkalosis

Answer 8

Sodium Bicarbonate

Question 9

Nerve deafness

Answer 9

Streptomycin

Question 10

CNS Defects

Answer 10

Vitamin A

Question 11

Goiter, Mental retardation

Answer 11

Iodides

Question 12

Cleft lip and Palate

Answer 12

Steroids

Question 13

Bleeding disorders

Answer 13

Barbiturate

Question 14

protozoan infection; spread through uncooked meat or contaminated soil or cat litter

Answer 14

• Toxoplasmosis

Question 15

most dangerous; can cause microcephaly, glaucoma, cataract, and mental retardation

Answer 15

• Rubella

Question 16

herpes virus; causes CNS damage

Answer 16

cytomegalovirus

Question 17

can cause severe congenital anomalies or abortion

Answer 17

• Herpes Simplex Virus

Question 18

HIGH IMMUNITY in the first 7 months; can have vaccine after delivery

Answer 18

• Chickenpox

Question 19

can cause fetal alcohol syndrome (mentally deficient, congenital abnormalities, low birth weight); can also cause abortion and prematurity

Answer 19

• Alcohol

Question 20

Nicotine can cause vasoconstriction resulting in decreased blood flow to the placenta which in turn diminishes oxygen supply to the fetus. Fetal hypoxia leads to low birth weight

Answer 20

• Smoking -

Question 21

Advise woman not to use or take any over-the-counter drugs

Answer 21

• Drugs

Question 22

• Toxoplasmosis:
  qS/sx:

Answer 22

malaise, lymphadenopathy
: can cause CNS damage to infant

Question 23

• Toxoplasmosis: MNGT:

Answer 23

SULFONAMIDES (Pyrimethamine)

Question 24

if mother got rubella advice?

Answer 24

advice mother to get vaccinated but NO PREGNANCY within 3 months

Question 25

Physiology of baby to a mother who’s smoking

Answer 25

• Nicotine can cause vasoconstriction resulting in decreased blood flow to the placenta which in turn diminishes oxygen supply to the fetus. Fetal hypoxia leads to low birth weight