Teratogenic Drugs Flashcards

0
Q

Anticholinergics

A

Neonatal meconium ileus

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1
Q

ACE inhibitors

A

Renal failure
Decreased skull ossification
Renal tubular dysgenesis

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2
Q

Antithyroid drugs

A

Hypothyroidism and goitre

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3
Q

Carbamazepine

A

Neural tube defects

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4
Q

Cyclophosphamide

A

CNS malformations

secondary cancer

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5
Q

Danazol and other antiandrogens

A

Masculinization of female fetus

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6
Q

Diethylbesterol

A

Vaginal carcinoma and other genitourinary defects

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7
Q

Hypoglycemic drugs

A

Neonatal hypoglycemia

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8
Q

Lithium

A

Cardiovascular defects

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9
Q

Methotrexate

A

CNS and limb malformations

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10
Q

Misoprostol

A

Morphological abnormalities

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11
Q

NSAIDS

A

Constriction or closure of the ductus arteriosus

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12
Q

Phenytoin

A

Growth retardation

CNS defects

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13
Q

Psychoactive drugs (barbiturates, opioids, benzodiazepines)

A

Neonatal withdrawal syndrome

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14
Q

Systemic retinoids

A

CNS
Craniofacial
Cardiovascular

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15
Q

Tetracycline

A

Anomalies of teeth and bone

16
Q

Thalidomide

A

Limb shortening

Internal organ defects

17
Q

Valproate

A

Neural tube defects

18
Q

Live vaccines

A

Risk of teratogenesis when immune compromised mother exposed

19
Q

Warfarin

A

Skeletal and CNS defects (bleeding into fetal brain)