Teratogenic Drugs

Question 1

Causes renal dysgenesis and craniofacial abnormalities

Answer 1

ACEi

use labetalol, methyl dopa or nifedipine for hypertension

Question 2

Cause craniofacial abnormalities

Answer 2

Alcohol and warfarin

Question 3

Causes ototoxicity

Answer 3

Aminoglycosides

Question 4

Causes neural tube defects and craniofacial abnormalities

Answer 4

Carbamazepine and Sodium Valporate

use lamotrigine

Question 5

causes grey baby syndrome

Answer 5

chloramphenicol

Question 6

causes IUGR and preterm labour

Answer 6

cocaine and smoking

Question 7

causes Ebstein’s anomaly (atrialized right ventricle)

Answer 7

Lithium (use lamotrigine)

Question 8

causes macrosomia, NTD, polyhydramnios and preterm labour

Answer 8

maternal diabetes

Question 9

cause discoloured teeth

Answer 9

tetracyclines e.g. doxycycline and tetracycline

Question 10

causes limb reduction defects

Answer 10

thalidomide

Question 11

causes skeletal defects

Answer 11

methotrexate

Question 12

antidepressant that may be associated with cardiac malformations

Answer 12

paroxetine (switch to sertraline or fluoxetine during pregnancy)

Question 13

which antipsychotic may be associated with agranulocytosis in the infant?

Answer 13

cloazapine (use olanzepine or quetiapine instead)