Teratogenesis

Question 1

List the 6 Principles (Wilsons Principles) of Teratogenesis

Answer 1

Genetics
Timing
Mechanism
Manifestation
Agent
Dose Effect

Question 2

What is the impact of androgens on a developing fetus?

Answer 2

Masculinisation of the female fetus

Question 3

What is the impact of alcohol on developing fetus?

Answer 3

Fetal alcohol syndrome:
- IUGR
- mental retardation
- microcephaly
- ocular and joint anomalies
- short palpebral fissures

Question 4

What is the impact of phenytoin on a developing fetus?

Answer 4

IUGR
Mental retardation
Facial anomalies

Question 5

What is the impact of Lithium on a developing fetus?

Answer 5

Cardiac anomalies

Question 6

What is the impact of methotrexate on a developing fetus?

Answer 6

Multiple malformations, often skeletal

Question 7

What is the impact of tetracycline on a developing fetus?

Answer 7

teeth staining and shortened long bones

Question 8

Nitrofurantoin in 3rd trimester

Answer 8

should be avoided from 36/40 due to risk of haemolytic anaemia of the newborn