Teponema and Brachyspira Flashcards
Bacteria that is the cause of syphilis
Treponema pallidum
Laboratory diagnosis of Treponema
This bacteria cannot be cultivated in the laboratory
Papillomatous digital dermatitis (PPD)
“Hairy Heel Warts”
Case of lameness of cows in the U.S. diary industry
Creates an economic loss - decreased milk production, lower reproductive efficiency
Treat - spray feet of dairy cattle with antibiotic (tetracycline or lincomycin) solutions while they are in the milking palor
Bacteria that of rabbit syphilis
Treponema paraluis-cuiculi
Vent disease in rabbits
Bacteria that causes swine dysentery
Brachyspira hyodysenteriae
Causes swine dysentery in actively growing pigs (6-12 weeks of age)
Characteristics of Brachyspira hyodysenteriae
Fibrinonecrotic pseudomembrane colitis
Obligate parasite of colon of pigs
Survives relatively poorly in environment, but will survive in anaerobic environment (e.g. manure0
Virulence factors of Brachyspira hyodysenteriae
Cytotoxin
Hemolysin
LPS
Transmission of Brachyspira hyodysenteriae
Fecal-oral
Asymptomatic carrier pigs are the most important mode of transmission from farm to farm
Mechanical vectors - boots, coveralls, migratory animals and birds
Pathogenesis of Brachyspira hyodysenteriae
Chemotactically attracted to hog mucin -> invades intestinal crypts and disrupts colonic epithelium -> erosion of superficial epithelium, excess mucus production, edema and hemorrhage of the lamina propria with pseuodomembrane formation -> death from dehydration
Absorption of bacterial endotoxins from gram-negative bacteria through damaged colonic mucosa can exacerbate symptoms
Diagnosis of Brachyspira hyodysenteriae
Direct staining and observation of loosely coiled spirochetes in clinical specimens
Fecal samples or tissues stained with Wright’s Giemsa, Victoria Blue Stain
This condition must be differentiated from Salmonellosis
