TDDS

Question 1

What is a drug delivery system?

Answer 1

It is a polymer or lipid carrier which delivers medication to it’s target site for maximum therapeutic effect, while avoiding toxicity and adverse effects. It does not degrade in the process.

Question 2

What are the two main classes of drugs delivery systems?

Answer 2

Particulate drug carriers
Macromolecular drug carriers

Question 3

State one example of a macromolecular DDS

Answer 3

Bioconjugates

Question 4

What are the components of a soluble macromolecular carrier?

Answer 4

Drug
Spacer and
Polymers such as poly (L-Lysine), poly (aspartic acid) and poly (vinylpyrrolidone)

Question 5

Name two examples of polymers used in liposomes

Answer 5

Phosphatidylcholine
Phosphatidylglycerol

Question 6

What’s the diameter of a liposome

Answer 6

0.02-5um

Question 7

Example of a drug carried in a liposome and state what it treats

Answer 7

Amphotericin B: For systemic mycoses

Question 8

State and explain the stages involved in the production of liposomes

Answer 8

Drying down of lipid from organic solvent
Disperse the lipid mixture on aqueous medium
Purification if the resultant liposome
Analyse the final product

Question 9

State advantages and disadvantages of liposomes carrier systems

Answer 9

Advantages:
-Enhanced cellular uptake
-Protects the medication against metabolism and degradation.
-Drug delivered just to one site and not dispersed in the body, hence great for cytotoxic drugs.

Disadvantages:
-Additional formulation studies (stability testing, Purity, leakage) needs to be done before marketing.

Question 10

Examples of polymers used in the production of microparticles include:

Answer 10

Gelatin
Ethyl cellulose
Polyvinyl alcohol
Cellulose acetate phthalate

Question 11

What are the two main methods used to produce microparticle

Answer 11

-Emulsion and interfacial polymerization
-Coacervation

Question 12

Advantages of microparticles

Answer 12

-Easy to design and formulate
-Provides sustained release of the medication for each microcapsules
-Multiple particle systems are distributed over a great length of the GIT, hence resulting in lowered concentrations and reduced toxicity and reduced variability in transit and absorption time.

Question 13

What’s the size of a nanoparticle

Answer 13

10-1000nm

Question 14

Examples of drugs used as part of nanoparticle include:

Answer 14

Doxorubicin
Methotrexate
Actinomycin D
5-flurouracil