TCA Cycle: Isocitrate Dehydrogenase Flashcards
1
Q
On what reducing agent is isocitrate dehydrogenase dependent?
A
NAD+
2
Q
What reactions does isocitrate dehydrogenase catalyze?
A
Oxidation and decarboxylation of isocitrate to alpha-ketoglutarate (an oxidation/reduction reaction)
3
Q
What is the first reaction in the TCA Cycle to produce CO2?
A
Isocitrate dehydrogenase
4
Q
What is the first reaction in the TCA Cycle to produce NADH?
A
Isocitrate dehydrogenase
5
Q
What cofactor is required by isocitrate dehydrogenase?
A
Mn2+ or Mg2+
6
Q
What role does the cofactor (Mn2+ or Mg2+) play for isocitrate dehydrogenase?
A
It helps polarize the newly formed carbonyl group of alpha-ketogluterate (the product)
7
Q
What is the intermediate in the isocitrate dehydrogenase step of the TCA Cycle?
A
oxalosuccinate
