TCA Cycle Flashcards
1
Q
Enzymes needing TLCFN
A
alpha-ketoglutarate DH
pyruvate DH
2
Q
Pyruvate DH
A
inhibited by arsenic; takes pyr–>acetyl coA (necessary for TCA cycle)
activated by NAD+, CoA, Ca2+
3
Q
isocitrate DH
A
regulatory enzyme in TCA cycle
if citrate is in cytosol, PFK1 will be inhibited (F6P–>F16BP)
meaning no glycolysis
Insulin prevents liver from being inhibited by this enzyme (glycolysis proceeds as normal)
4
Q
Citrate synthase
A
catalyzes 1st reaction
activated by ADP
5
Q
Isocitrate DH
A
catalyzes oxidative decarboxylation of isocitrate
activated by ADP and Ca2+
6
Q
alpha-ketoglutarate DH
A
TLCFN
activated by Ca2+ and AMP
7
Q
TCA cycle enzyem deficiency
A
mitochondrial myopathy
fluroacetate/flurocitrate inhibits aconitase
no TCA cycle
