Pentose Phosphate Pathway/HMP Shunt Flashcards
1
Q
HMP shunt purpose
A
makes NADPH and ribose sugars
2
Q
Transketolase
A
gene that binds thiamine to make sugar products for the brain
3
Q
Transketolase deficiency
A
inability to bind thiamine and make sugar products decreases brain function
4
Q
Wernicke Korsakoff disease
A
mutation in transketolase gene
treatment: thiamine
5
Q
Thiamine deficiency
A
called Beriberi; all 4 thiamine enzymes don’t work
alcoholics develop this eventually because alcohol inhibits thiamine absorption
6
Q
G6PD deficiency
A
no NADPH made–>no reduced glutathione
cell does not get detoxified; H2O2 will not become H2O
Hemolytic anemia, Heinz bodies
