Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Psychopathology > TC1 drugs > Flashcards

TC1 drugs Flashcards

1
Q

Buproprion
dual mechanism agent

neurochemistry:
advantages:
disadvantages:

A 
NEUROCHEMISTRY: enhances DA and NE. no 5HT
.
ADVANTAGES: 
no sexual side effects
good for depressed Parkinson's pts (boosts DA)
no weight gain
no P450 interactions
reduces nicotine craving

DISADVANTAGES:
increased seizure risk (DA)
doesn’t work for panic disorder or OCD
contraindicated in bulimics or history of seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Venlafaxine

dual mechanism agent

A 
NEUROCHEMISTRY: at higher doses blocks NE (and maybe DA) reuptake. DO NOT combine with MAOI's!
ADV:
little to no weight gain
minimal sedation
no P450 interactions
higher dose will have more effect
DISADV:
has all 5HT side effects
increases BP
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Duloxetine

dual mechanism agent

A

NEUROCHEMISTRY: at starting doses blocks reuptake of NE AND 5HT. do not combine with MAOI’s! interacts with P450

ADV: better for depressed chronic pain pts

DISADV: all 5HT side effects, some anticholinergic side effects, interacts w/ P450

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Mirtazapine

dual mechanism agent

A

NEUROCHEMISTRY: 1) blocks alpha-2 -> disinhibit 5HT
2) blocks 5HT 2 and 3 receptors -> minimize serotonin side effects
ADV: less sexual side effects
no P450 interactions
DISADV: sedating, weight gain, more side effects at lower doses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

side effects of MAOI’s

A
  1. HYPERTENSIVE CRISIS: from increased NE and also more tyramine from fermented foods can enter blood
    .
  2. HYPERMETABOLIC CRISIS (serotonin syndrome): fever, NM irritability, altered consciousness -> coma, seizures, possible death. caused by giving MAOI w/ 5HT level raising med (common cold meds, ecstacy, ALL SSRI’s)
    .
  3. all side effects of blocked ACh, alpha 1, and histamine receptors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Lithium

affects which 2nd messenger pathway

pros:
cons:
side effects:

A

Phosphatidylinositol (PI) 2nd messenger

pros:
lowers suicide rates

cons:
narrow therapeutic window. must moniter blood levels closely! avoid dehydration and kidney disease/reduced function
less likely to help “rapid cycling” bipolar pts (>4 episodes/year)

side effects: upset GI, termors, weight gain, increased thirst and urination, hypothyroidism, delayed cardiac conduction, kidney abnormalities

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

name all the SSRI’s (6)

mnemonic: Effective FFor Sadness, Panic, and Compulsions

A 
Escitalopram
Fluvoxamine
Fluoxetine
Sertraline
Paroxetine
Citalopram
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

clean drugs (6)

mnemonic: Venlafaxine Doesn’t MenD Bulimia

A

Venlafaxine
Desvenlafaxine
Mirtazapine

Dulxetine
Bupropion (only one that works on DA and not 5HT). do not give to pts with bulimia or seuzures
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

dirty drugs: TCAs and MAOIs.

TCAs: CAIND

MAOIs: PS

A 
TCAS:
Clomipramine
Amitriptyline
Imipramine
Nortriptyline
Desipramine
.
MAOIs:
Phenelzine
Selegiline patch (only reversible one)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Mood stabilizer drugs: (6)

Vanessa Likes To Call LOvers

A 
Valproate
Lithium
Topiramate
Carbamazepine
Lamotrigine
Oxcarbazepine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Name the 4 Benzodiazepine anxiolytics:

A
  1. Alprazolam
  2. Lorazepam
  3. Clonazepam
  4. Diazepam
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

name the 2 non-benzos anxiolytics

A
  1. Zolpidem

2. Buspirone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

alpha blocker for PTSD and other SNS overactivity?

A

Prazosin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

First generation Antipsychotics/Neuroleptics

A
  1. Chlorpromazine
  2. Loxapine
  3. Haloperidol
  4. Fluphenazine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

2nd generation/atypical antipsychotics

A
  1. Clozapine
  2. Risperidone
  3. Olanzapine
  4. Quitiapine
  5. Ziprasidone
  6. Aripiprazole
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

which drugs are helpful in bipolar disorder, during a manic episode and to prevent future episodes?

A
  1. mania - 2nd generation antipsychotic

2. prevent episodes - Olanzapine

17
Q

mechanism of action of first generation Antipsychotics?

A

block DA-2 receptors in mesolimbic pathway

18
Q

mechanism of action of 2nd generation Antipsychotics?

A

block DA-2 receptors AND act as 5HT receptor agonists which decrease side effects

19
Q

what unique side effect does Risperidone have as a 2nd gen antipsychotic?

A

only 2nd gen to have endocrine Side effects (increase prolactin). this is usually a first generation side effect

20
Q

side effects of clozapine

A 
weight gain
agranulocytosis
drooling
worst metabolic effects of 2nd gen antipsychotics
myocarditis
lowered seizure threshold

Psychopathology (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions