tbl 9 Flashcards
what is the vasodilator theory
↑ formation and release of potent local vasodilators ____________
↑ formation and release of potent local vasodilators (e.g, adenosine, nitric oxide, CO2, histamine, bradykinin, hydrogen, lactate, potassium, etc) by the affected tissues
Oxygen or Nutrient demand theory
in what type of tissue
what vasodilator released ?
metabolic theory
myogenic theory
↓↓ supply of oxygen and/or ↑↑ accumulation of carbondioxide (hypercapnia) or
hydrogen or potassium or lactate
Intrinsic control (autoregulation) of blood flow in brain:
active vs reactive hyperemia
V. Humoral control of tissue blood flow:
a) Emergencies, stress, and exercise, etc→ ↑↑ activation of Sympathetic nervous system
- ↑ Norepinephrine (Noradrenaline)– binds with_______
- ↑ Epinephrine (Adrenaline)– binds with _______
Vascular injury, chronic hypertension, advanced atherosclerosis, sheer
stress, use of drugs (e.g, ________ for treatment of angina pectoris,
_________ for treatment of erectile dysfunction) lead to an increase of _______ which does what ? mechanism of action
nitroglycerine for treatment of angina pectoris,
sildenafil for treatment of erectile dysfunction),
Tissue injury (inflammation), and allergic reactions– leads to:
inc of what vasodilators
Dehydration, hypovolemia, hypotension, etc– leads to:
the formation of what?
Dehydration, hypovolemia, etc– leads to:
the formation of what?
injury to vascular endothelium resulting in bleeding: releases_____
physical or chemical injury to vascular endothelial cells
releases
what happens with Long-term (days to months) regulation of tissue blood flow?
factors that inc angiogenenesis and factors that decrease it?
blockage leads to ___
factors that induce angiogenesis
factors that decrease angiogensis
