TBL Flashcards

1
Q

What is sucrose composed of

A

disaccharide of glucose and fructose

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2
Q

What is the constituents of high fructose corn syrup

A

40 glucose, 60 fructose

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3
Q

What pathway converts glucose to fructose

A

Polyol biochemical pathway

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4
Q

Where is fructose exclusively metabolized?

A

The liver

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5
Q

What is the enzyme that metabolizes fructose

A

Ketohexokinase

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6
Q

T/F the conversion of fructose to fat is unregulated

A

TRUE

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7
Q

What are the side effects of a diet high in fructose

A

Insulin resistance, visceral oversight, and elevated levels fo lipid TAGS

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8
Q

ATP synthesis is driven by

A

Oxidative phoshorylation via the Krebs cycles

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9
Q

What happens to pyruvate if it is being generated faster than it can enter the Krebs cycle

A

It is converted to lactate

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10
Q

Which type of muscle fibers typically take up lactate

A

Slow twitch (Type 1)

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11
Q

What is the exponential rise in lactate known as

A

Lactate threshold

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12
Q

T/F the ventilatory threshold and the lactate threshold occur at different times

A

False

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13
Q

What tissues require insulin for glucose uptake at rest

A

Skeletal, liver, adipose

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14
Q

How does the brain uptake glucose

A

Facilitated diffusion: doesn’t need insulinn

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15
Q

What is the balance for blood gradient of glucose

A

Having enough glucose to maintain the gradient for the brain, but also be able to have enough to use skeletal muscle

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16
Q

Liver and pancreas use what GLUT transporter

A

GLUT 22

17
Q

Brian uses what GLUT transporter

A

GLUT 3

18
Q

Skeletal muscle uses what GLUT transporter? Which is insulin independent?

A

GLUT 1,4; Glut 4

19
Q

What holds the GLUT 4 transporters open for the uptake of insulin?

A

Calcium

20
Q

What organ produces insulin

A

Pancreas

21
Q

What are the two key adjustments for maintaining sufficient blood-glucose

A
  1. Alpha adrenergic mediated inhibition of beta cells of pancreas
  2. The liver begins driving gluconeogenesis and glycogenolysis to shuttle glucose to the blood