TB therapeutics Flashcards
What does the TST test stand for?
PPD
What does the IGRA test stand for?
Quantiferon
Test results for TB with innate immune response (infection eliminated).
- Negative in all tests
- Not infectious
Test results for TB with acquired immune response (infection eliminated).
- Positive in TST and IGRA
- Negative in all others
- Not infectious
Test results for latent TB infection.
- Positive in TST and IGRA
- Negative in all others
- Not infectious
- Preventative therapy
Test results for subclinical TB disease.
- Positive in TST, IGRA, culture
- Negative in all others
- Sporadically infectious
- Multidrug therapy
Test results for active TB infection.
- Positive in TST, IGRA, culture, sputum smear
- Infectious
- Multidrug therapy
What is drug susceptible TB?
TB strains that are sensitive to the standard 1st line agents
What is monoresistant TB?
TB strains that are sensitive to just one anti-TB drug
What is polyresistant TB?
TB strains that are resistant to more than one anti-TB drug but not INH and RIF
What is MDR TB?
TB strains that are resistant to RIF and INH
What is XDR TB?
TB strains that are resistant to RIF and INH + at least one injectable agent (amikacin, kanamycin, or capreomycin) + any of the FQs
What is the mutation rate of rifampin?
10^-8
What is the mutation rate of isoniazid and pyrazinamide?
10^-6
What is the standard 6 month regimen for TB?
Intensive phase for 8 weeks:
- Rifampin 600 mg +
- Isoniazid 300 mg +
- Pyrazinamide 1,000-2,000 mg +
- Ethambutol 800-1,600 mg once/day
Continuation phase for 18 weeks:
- Rifampin 600 mg +
- Isoniazid 300 mg once/day
What is the rifapentine-based 4 month treatment for TB?
Intensive phase for 8 weeks:
- Rifapentine 1,200 mg +
- Isoniazid 300 mg +
- Moxi 400 mg +
- Pyrazinamide 1,000-2,000 mg once/day
Continuation phase for 9 weeks:
- Rifapentine 1,200 mg +
- Isoniazid 300 mg +
- Moxi 400 mg once/day
