Malaria therapeutics Flashcards
What are the prophylaxis options for ‘all malaria-endemic regions?’
- Atovaquone/proguanil
- Doxy
- Tafenoquine
What are the prophylaxis options for ‘regions with chloroquine-sensitive malaria?’
- Chloroquine
- Hydroxychloroquine
What is the prophylaxis option for ‘regions primarily with P. vivax?’
Primaquine
What is the prophylaxis for ‘regions with mefloquine-sensitive malaria?’
Mefloquine
What are the s/sxs of malaria?
- Fever
- Headache
- Weakness
- Rigors
- Night sweats
- Insomnia
- Arthralgias/myalgias
- NVD
- Neurologic complications
What are the s/sxs for malaria to be considered severe?
If they have >/= 1 of the following:
- Impaired consciousness/coma
- Hemoglobin <7 g/dL
- AKI
- ARDS
- Circulatory collapse/shock
- Acidosis
- Disseminated intravascular coagulation
- Parasite density >/= 5%
What are the treatment options for malaria that is choloroquine-resistant or unknown resistance?
- Artemether/lumefantrine (Coartem)
- Atovaquone/proguanil (Malarone)
- Quinine + doxy, tetra, or clinda
What is the treatment option for malaria that is chloroquine-resistant, no mefloquine resistance, or unknown resistance?
Mefloquine
What are the treatment options for malaria that is chloroquine sensitive?
- Chloroquine
- Hydroxychloroquine
What are the treatment options for malaria that is P. vivax or P. ovale?
- Primaquine
- Tafenoquine
What are the treatment options for malaria that is P. knowlesi or P. malariae?
- Chloroquine
- Hydroxychloroquine
What is the treatment for severe malaria?
IV artesunate
After finishing IV artesunate for severe malaria, what are the oral treatment options to transition to?
- Preferred: artemether/lumefantrine
- Atovaquone/proguanil
- Quinine + doxy or clinda
- Mefloquine
