TB Immunology Flashcards
1
Q
What causes bovine Tb?
A
m. bovis (bacteria)
2
Q
What is TB?
A
zoonotic Respitory disease
3
Q
What are the symptoms of Tb in cattle?
A
- weight loss
- cough
- fever
- latency can occur
4
Q
What is primarily exposed when cattle are infected?
A
- airway epithelial cells
- tissue resident macrophages (primary cellular host)
- dendritic cells
5
Q
What do aveolar macrophages and dendritic cells do to fight TB infection?
A
phagocytose TB
6
Q
how do dendritic cells respond to TB infection?
A
- migrate to draining lymph nodes to prime T cells
7
Q
How do macrophages and T cells work together during TB infection?
A
- form a cellular complexes to wall of the infection
8
Q
How long can the infection be latent?
A
10-20 years
9
Q
Active cases of TB can cause what?
A
Spreading of the disease
10
Q
What occurs to make TB active?
A
Infection is not contained or granuloma ruptures
11
Q
How do macroophages work against Tb?
A
- cytokine response
- engulf infected cells
12
Q
How is the granuloma formed
A
- immune cells aiming to contain TB
