TB Drugs

Question 1

1. M TB converts using KatG to a metabolite that disrupts mycolic acids
2. inhibits prokaryotic DNA dependent RNA polymerase
3. Uncertain MOA but inhibits mycolic acid biosynthesis
4. inhibits arabinosyl transferase
5. binds 30s ribosome to disrupt protein synthesis
6. direct inhibitor of bacterial DNA synthesis by disuprting DNA gyrase and topoisomerase
7. inhibits mycolic acids
8. disrupts folic acid pathway
9. inhibits cell wall synthesis
10. binds 23s ribosomal subunit of the 50s subunit
11. inhibits mycobacterial ATP synthesis

Answer 1

1. Isoniazid
2. Rifampin
3. Pyrazinamide
4. Ethambutol
5. streptomycin
6. fluoroquinolone
7. ethionamide
8. P-aminosialcylic acid (PAS)
9. cycloserine
10. linezolid
11. Bedaqiline