TB drugs

Question 1

rifamycins MOA

Answer 1

inhibit DNA-dependent RNA polymerase

Question 2

rifamycins AE

Answer 2

hepatoxic, induce CYP P450

Orange body fluids

Question 3

Why rifabutin in HIV

Answer 3

less CYP P450 stimulation (drug interactions)

Question 4

Isoniazid MOA

Answer 4

decrease synthesis of mycolic acids

Peroxidase (encoded by KatG) needed to convert INH into active metabolite

Question 5

Only agent used as sole prophylaxis against TB

Answer 5

isoniazid

Question 6

Isoniazid AE

Answer 6

INH - injures Neurons and Hepatocytes

Question 7

Pyrazinamide MOA

Answer 7

uncertain

is a prodrug converted to active compound pyrazinoic acid

Question 8

pyrazinamide AE

Answer 8

hyperuricemia, hepatotoxicity

Question 9

Ethambutol MOA

Answer 9

decrease carbohydrate polymerization of mycobacterium cell wall by blocking arabinosyltransferase

Question 10

ethambutol AE

Answer 10

optic neuropathy (red-green color blind)

Question 11

Streptomycin MOA

Answer 11

(aminoglycoside)
bactericidal
irreversible inhibition of initiation complex of 30S subunit – misread mRNA – block translocation

Question 12

streptomycin AE

Answer 12

nephrotoxic, neuromuscular blockade, ototoxicity, teratogenic