TB drugs

Question 1

Which drug inhibits synthesis of mycolic acids? Prodrug activated by KatG (a mycobacterial catalase-peroxidase)?

Answer 1

Isoniazid

-must be activated

Question 2

Which drug binds the beta subunit of bacterial DNA-dependent RNA polymerase and inhibits RNA synthesis?

Answer 2

Rifampin

-induces cytochrome p450

Question 3

Which drug inhibits mycobacterial arabinosyl transferase? Associated with loss of visual acuity and color blindness?

Answer 3

Ethambutol - prevents cell division

Question 4

Which drug is a prodrug, disrupts mycobacterial cell membrane metabolism and transport functions, and can cause gouty arthritis?

Answer 4

Pyrazinamide

-cidal against actively dividing TB; active in macrophages

Question 5

Which drug only binds a bacterial 30s ribosomal subunit? an aminoglycoside? Mostly extracellular?

Answer 5

Streptomycin

-bactericidal

Question 6

Which drug is a supplement (vit B6) given with Isoniazid?

Answer 6

Pyridoxine

-to prevent peripheral neuropathy

Question 7

Which drug is a folate synthesis antagonist?

Answer 7

Aminosalicylic Acid (PAS)
-static

Question 8

Which drug inhibits cell wall synthesis? Structural analog of D-alanine

Answer 8

Cycloserine

-static