HIV Drugs

Question 1

Which drug is a CCR5 inhibitor?

Answer 1

Maraviroc

Question 2

What is Enfuvirtide?

Answer 2

a fusion inhibitor; interacts with gp41 on virus to prevent fusion

Question 3

What class are zidovudine, lamivudine, abacavir, tenofovir, and emtricitabine?

Answer 3

NRTIs; inhibit DNA polymerase, and require intracellular activation

Question 4

Which drug is a NRTI, is a deoxythymidine analog, and mutation of reverse transcriptase causes resistance?

Answer 4

Zidovudine (AZT)

Question 5

Which drug is a NRTI, cytosine analog, and is synergistic with other nucleoside analogs?

Answer 5

Lamivudine

Question 6

Which drug is a NRTI, guanosine analog, and causes rash adversely?

Answer 6

Abacavir

Question 7

Which NRTI is a nucleoside analog of adenosine?

Answer 7

Tenofovir

Question 8

Which NRTI is a flourinated analog of lamivudine so it has a longer intracellular half life?

Answer 8

Emtricitabine

Question 9

What class of drugs are Efavirenz and Etravirine?

Answer 9

NNRTIs - don’t need to be activated like NRTIs

Question 10

Which NNRTI allosterically inhibits reverse transcriptase?

Answer 10

Etravirine

Question 11

Which NNTRI binds directly to the reverse transcriptase and causes allosteric inhibitiron?

Answer 11

Efavirenz

Question 12

Which drug is an integrase inhibitor (binds integrase and inhibits strand transfer)?

Answer 12

Raltegravir

Question 13

Which drugs are protease inhibitors?

Answer 13

Atazanavir - inhibits viral protease from cleaving precursors into final structural proteins so virus can’t mature
Darunavir
Ritonavir

Question 14

Which drug is used to boost concentrations of other drugs by inhibiting CYP3A4?

Answer 14

Ritonavir