TB drugs

Question 1

Adverse effects of Isoniazid.

Answer 1

CHANGE

1) Change in memory
2) Hepatotoxic and Hallucinations
3) Anemia
4) peripheral Neuropathy (Isoniazid inhubits production of Pyridoxal phosphate from Pyridoxine— this side effect can be prevented by giving 10mg/day pyridoxine prophylactically)
5) Gynecomastia
6) Euphoria (and other CNS effects like convulsions etc)

Question 2

Name 2 drugs which cause discoloration of body fluids and secretions.

Answer 2

1. Rifampicin: orange-red discoloration of body fluids— may stain contact lenses
2. Clofazimine: Reddish-black or Orange-brown discolouration of body fluids and skin

Question 3

Effects of anti-TB Drugs based on multiplication rate of bacteria.

Answer 3

Isonizid: Fast multiplying
Rifampicin: Slow multiplying
Pyrazinamide: Slow multiplying (intercellular)
Ethambutol: Fast multiplying

Question 4

Mechanism of action of Bedaquiline.

Answer 4

Inhibits Mycobacterial ATP Synthase, prevents energy production.
It is strongly bactericidal.