TB and other random things

Question 1

Isoniazid HCl

Answer 1

first line drug for active TB, used in combination. activated by catalase peroxidase, and targets the inhA gene product found in the cell wall

Question 2

What are the resistance mechanisms for isoniazid HCl?

Answer 2

Mutations in the KatGgene and mutations in the inhA gene

Question 3

What are the AE of isoniazid?

Answer 3

hepatotoxicity, neurotoxicity, hypersensitivyt reactions

Question 4

ethambutol

Answer 4

first line TB therapy, helps inhibit resistance to other drugs. inhibits TB arabinosul transferase encoded by embB gene

Question 5

What are the AE for ethanbutol?

Answer 5

optic neuritis, peripheral neuropathy

Question 6

Pyrazinamide

Answer 6

first line TB drug, used for the 1st two months of therapy.

Question 7

Streptomycin

Answer 7

second line TB drugs

Question 8

Multidrug resistant TB

Answer 8

resistant to both INH and refampin

Question 9

If tb is rifampin resistant, how is treatment different?

Answer 9

No 6 course therapy available, must have therapy for 18-24 months

Question 10

What is the 6 month protocol?

Answer 10

RIPE: rifampin, INH, pZA, ethambutol