TB

Question 1

What is the standard treatment regimen for TB?

Answer 1

2 HRZE/ 4HR

Question 2

What is latent treatment for TB?

Answer 2

3HR/6H

Question 3

What is treatment for TB in isoniazid resistance?

Answer 3

2 RZE/ 7RE

Note: 2HRZE/ 4RZ if H resistance unknown
6-9 RZE + fluroquinolone if H resistance
6 RZE + fluroquinolone in extensive disease

Question 4

What is treatment in CNS infection?

Answer 4

2HRZE/10HR (NICE recommend 9 month minimum, WHO 12 month)
Adjunctive steroids

Question 5

What is the regime in treatment interruption?

Answer 5

Low risk MDR: 2 HRZES/1HRZE/5 HRE

Question 6

MDR/RR-TB

Answer 6

All 3 group A drugs: Bdq, Lzd, Lfx/Mfx + 1 group B drug:
CFZ, Cs/trd with injectable intensive phase 8 months.

Bedaquinine - Pretomanid - Linezolid - Moxifloxacin 6/12

Question 7

MDR/ RR-TB oral treatment

Answer 7

6Bdq-Lfx-Cfz-Z-E-Hh-Eto/ 5 Lfx-CPx - Z -E

Question 8

How to treat Pyrazinamide resistant TB

Answer 8

2RHE/7RH

Question 9

How to treat Ethambutol resistant TB

Answer 9

2RHZ/ 4RH

Question 10

How to treat NTM:
MAC, malmoense

Answer 10

RE + clari/azithro

Question 11

How to treat NTM:
xenopi

Answer 11

Rifampicin, Ethambutol + macrolide(Clari/azithro) + quinolone/iso

Question 12

How to treat NTM: Kansasii

Answer 12

Rifampicin + Ethambutol +macrolide/isoniazid

Treatment should continue 12 months following culture coversion on sputum

Question 13

How to treat mycobacterium abscessus

Answer 13

4 weeks Iv amikaci, tigecylcline, imipenem and oral clarithromycin then
Nebulised amikacin + clar/azithro +
either doxy/moxi/cipro/co-trimox/linezolnid/clofazimine