TB Flashcards
1
Q
TB drugs
A
- Isoniazide
- Rifampin
- Pyrazinamide
- Ethambotul
2
Q
Isoniazide MOA
A
Mycolic acid
Cidal & Static
3
Q
INH Resistance
A
- katG gene
- INHA gene
4
Q
INH kinetic
Metabolism, Clearance
A
- First phase 2 in liver then 1
- Fast & slow acetylator
- Urine clearance
5
Q
INH side effects & interaction
A
- Neural
- Hepatic (Toxicity & Hepatitis)
- Lupus-like syndrome
- G6PD hemolytic anemia increase
- Inhibit carbamazepin, phenytoin, warfarin
Vit B6 decrease increases side effects
6
Q
INH other uses
A
- TB prophylaxis
- Delayed infections
7
Q
Rifampin MOA
A
RNA polymerase inhibition
Cidal
8
Q
RIF resistance
A
rpo gene
9
Q
RIF kinetic
A
- even CNS
- Bile
- Enterohepatic
- Clearance fecal
10
Q
RIF side effects
A
- Proteinuria
- Immune response problem
- Rash
- Hepatic failure
- if <2 in a week: flu-like & anemia
- Orange body fluids
11
Q
RIF interactions
A
CYP450 inducer
Decreases:
1. Anti convulsants
2. OCPs
3. Warfarin
4. some Antifungals (ketoconazole)
5. HIV drugs (esp. protease inhibitors)
12
Q
RIF other uses
A
- INH alternative
- Leprosy next to dapson
- w/ vanco for MRSA & Pen resistants
- Staph & meningococcus carriers
13
Q
Other rifamycins
A
- Rifabutin: like RIF but less interactions
- Rifapentine: can be used weekly
- Rifaximine: ONLY traveller’s diarrhea
14
Q
PZA MOA
A
- Cidal
- Pro drug
- Not known
15
Q
PZA resistance
A
- gene
- efflux
