Taylor veneziani_ Aorta

Question 1

What happens to aorta as you age

Answer 1

becomes stiffer (decrease capacitance)

Question 2

epidemiology of abdominal aortic aneurysm

• gender
• age
• risk factor
• other co-morbidities
• most common symptom

Answer 2

• males
• older white males
• smoking
• other vascular symptoms (ED)
• FH
• back pain can happen, but mainly asymptomatic

Question 3

What is the most common site of aneurysms? where specifically?

How much of the aorta is involved

Answer 3

• abdominal aorta, particularly below the renal arteries

- TRANSMURAL; involves all layers of aora

Question 4

T/F HTN and Cholesterol are main risk factors of AAA

Answer 4

F; FH, smoking, and age are the biggest

Question 5

two ways to repair AAA

Answer 5

• Endovascular repair (catheter-based)

- surgery

Question 6

Marfan syndrome:

- degeneration of what? due to what mutation?

Answer 6

• degeneration of tunica media, where smooth muscle is

- mutation in fibrillin -1, resuliting in loss of inhibition of TGF- beta

Question 7

what is the result of losing inhibition of TGF-beta?

Answer 7

• results in activation of MMP and inflammation

Question 8

in silico = “_____”

Answer 8

• computational medicine; modeling/simulation/visualization