Taylor: ANS Flashcards
ANS:
- Automatic, not voluntary
- has both afferent and efferent fibers
- receives input from afferent fibers
- efferent fibers respond to changes from afferent
- Reflexes
- Regulates
- cardiovascular and digestive systems
- body temp
- glandular secretions
- metabolism
- Protects and/or maintains homeostasis
Autonomic nervous system innervates:
- smooth muscle
- cardiac muscle
- exocrine galnds
3 classification schemes for ANS:
- Anatomical
- Preganglionic fibers
- Postganglionic fibers
- Actions:
- Trophotrophic (nutritive)
- Ergotrophic (work related)
- Chemical:
- Primary Neurotransmitter
- Actylcholine (Cholinergic)
- Norepinephrine or Epinephrine (noradrenergic/adrenergic)
- Primary Neurotransmitter
Anatomical Classification:
Preganglionic vs Postglanglionic fibers
- Parasympathetic:
- Long preganglionic fibers
- most innervate ganglia in the walls of the tissue
- some innervate ganglia located outside organs
- derived from craniosacral origin
- sacral spinal cord (S2-S4)
- Cranial N-3, 7, 9, 10
- Short postganglionic fibers located near or in tissues
- discrete innervation
- Long preganglionic fibers
- Sympathetic:
- Short preganglionic fibers from interomedial lateral cell column of spinal cord
- most innervate ganglia distant from effector tissue in paravertebral chains that run down both sides of vertebral column
- Origin: Thoracolumbar origin (T1-L2)
- Long Postganglionic fibers
- single fiber
- exits ganglia and innervates many cells in many tissues
- 1 fiber: 100s of cells
- exits ganglia and innervates many cells in many tissues
- Distribuation innervatin pattern
- single fiber
- Short preganglionic fibers from interomedial lateral cell column of spinal cord
List all Cranial Nerves
Oh Oh Oh To Touch And Feel A Girls Vagina, Ah Hell
- Olfactory
- Optic
- Occulomotor
- Trochlear
- Trigeminal
- Abducens
- Facial
- Adutiory (Vestibulocochlear)
- Glossopharyngeal
- Vagus
- Accessory (spinal accessory)
- Hypoglossal
Actions Classification:
Trophotrophic (Nutritive) vs Ergotrophic (Work related)
- Trophotropic Action=PNS
- accumulation and storage of energy reserves
- “feed and breed, Rest and Digest” or “Rest and Repair”
- No wide spread Activation
- Functions on organ-specific basis
- Activities:
- SLUDGE
- Salivation, Lacrimation, Urination, Defecation, GI motility, and Erection
- DUMBBELLS
- Diarrhea, Urination, Miosis, Bradychardia, Bronchospasms, emesis, Lacrimation, Salivation, & Seizures
- SLUDGE
- Ergotrophic- Sympathetic
- energy expenditure system
- “Fight, Fright, or Flight”
- wide spread activation
Chemical Classification:
Chemical: Primary NT
- Cholinergic Neurons
- NT: Acetylcholine
- released from
- somatic motor nerve endings
- autonomic ganglia
- parasympathetic postganglionic nerve endings
- sympathetic neurons innervating sweat glands
- released from
- NT: Acetylcholine
- Adrenergic or Noradrenergic Neurons
- NT: Norepinephrine
- released from sympathetic postganglionic nerve endings
- except: Sympathetic neurons that innervate sweat glands=cholinergic=Ach
- released from sympathetic postganglionic nerve endings
- NT: Norepinephrine
ANS: Dual Innervation
- Both Parasympathetic and Sympathetic NS innrvate same organ
- Work in opposition w/each other in:
- cardiovascular system
- salivary glands
- urinary bladder
- Bronchial Tree
- Net effect depends on:
- innervation present
- Blood vessels, spleen, piloerector muscles, and sweat glands=ONLY Sympathetic
- NT= NE except Ach for sweat glands
- Blood vessels, spleen, piloerector muscles, and sweat glands=ONLY Sympathetic
- Predominant Tone (Central activation)
- Receptor Present
- innervation present
Parasympathetic Receptors:
Cholinergic Neurons
- NT: Ach
- somatic motor
- all autonomic ganlia
- all parasympathetic postganglion
- sympathetic sweat glands
- Muscarinic Receptors:
- M1, M3, M5
- Gq–> PLC–>DAG & IP3–> Increase in intracellular Ca2+, Activation of PLD2 and PLA2
- Autonomic Nerve depolarization
- Smooth m. contraction (Bladder)
- M2, M4
- Gi–> inhibits adenylyl cyclase–>Decrease cAMP–>opening of inward rectyifying K+ channels, inhibition of voltage-gated Ca2+ channels
- Hyperpolarization, Decrease HR, Decreased ganglion NT release, SM contract
- M2 linked directly to the opening of K+ channels
- M1, M3, M5
- G-Protein coupled receptors
- Location
- M1: Autonomic ganglia
- modify effects of nicotinic receptor activation\
- M2: Heart
- M3: Glands & SM
- M4/M5: unknown
- M1: Autonomic ganglia
Sympathetic receptors
- Adrenergic/Noradrenergic
- Norepinephrine (E)
- sympathetic postgangliionc nerve endings except SWEAT glands
- Norepinephrine (E)
- a1
- a1a, a1b, a1d
- Gq=same as M1,M3, M5
- a2
- a2a, a2b, a2c
- Gi=same as M2, M4
- Not always: BV–>Increase Ca2+
- beta/gamma subunit of g protein–Hyperpolarizes heart
- A2
- Postganglion
- primarily actived by epinephrine
- Preganglion=Autoreceptor
- presynatpic inhibtion
- bound on adrenergic and cholinergic nerve terminals
- inhibit release of Ach from muscarinic
- activated by NE or agonist
- Decrease release of NT
- If you block a2 receptor
- enhance NE release
- Postganglion
- B
- B1, B2, B3
- B2=always relaxation
- low affinity for NE
- adrenal glands release E and activates
Eye:
- Iris:
- radial m. (dilator m.); Tone=A
- SNS-contrct=a1
- PNS=n/a
- circular m. (Sphincter m.); Tone=C
- SNS: n/a
- PNS: contract= M3
- radial m. (dilator m.); Tone=A
- Ciliary M.; tone=C
- SNS: relax=B2
- PNS: contract=M3
Lacrimal Glands
- Tone=C
- SNS: secretion; a
- PNS: secretion: M3
GI Tract:
ALL TONE C
- Motility & Tone:
- SNS: relax-a1, a2, B1, b2
- PNS: contract: M3
- Sphincter:
- SNS: Contract=a1
- PNS: relax: M3
- Secretion:
- SNS: n/a
- PNS: increase-M3
Repiratory Tract:
- Bronchiole SM: Tone C
- SNS: Relaxtion, but NO INNVERVATION=B2
- PNS: Contract=M3
Salivary Glands
Dual innervation
- SNS: secretion: a1
- PNS: secretion M3
Sweat Glands:
- Actionable=Sympathetic, but release Ach
- Tone: C
- Local Secretion:
- SNS: a1
- General secretion:
- PNS: M3
Blood vessels
- sympathetically innverate ONLY
- have muscarinic receptors that live in endothelial cells-release nitric oxide
- B2=coronary artery, SKM, pulmonary a. veins
Heart
Tone=All C, but ventricle
- SA node:
- SNS: increase-B1
- PNS: decrease-M2
- Atria:
- SNS: increase-B1
- PNS: decrease-M2
- AV Node
- SNS: increase=B1
- PNS-Decreaes-M2 (AV block)
- His-Purkinje System (Conduction system)
- SNS: Increase-B1
- PNS: little effect-M2
- Ventricle: TONE=A
- SNS: increase-B1
- PNS: slight decrease-M2
Parasympathetic affects primarily rate and conduction
Sympathetic affects rate, conduction, and force of contraction
What is the most difficult phase of endodontic treatment?
Access cavity prep
Access Cavity Preparation: Objectives
- Remove the roof of the pulp chamber
- Remove all coronal pulp tissue
- Locate all canals
- establish straight line access
- conserve tooth structure
Rubber dam
- do not begin access until rubber dam places
- exceptions:
- teeth tipped, rotated, extremely calcified
- exceptions:
- is the standard of care
- 53% do not use
- seal around clamp with cavit or oraseal to prevent leaks=contamination
26N clamp
Displaces the dam
minimal interferance with radiographs
What if there is not enough tooth to hold clamp?
- slit dam
- clamp to soft tissue
Krasner Paper
Anatomy of Pulp-Chamber floor
- Pulp chamber always in the center of tooth at CEJ
- pulpal floor-darker
- pulpal roof-yellowish/white
- orifices of the root canals always located at th jxn of the wall and pulpal floor
Deutsch
- Roof of the pulp chamber was found at CEJ in maxillary and mandibular molars=97-98%
- Maxillary and mandibular molars
- 7mm from cusp tip to middle of pulp chamber
- Maxillary premolars
- 7mm from cusp tip to the roof of pulp chamber
Lee paper
- Anterior teeth
- 4.5-6mm from lingual surface to pulp chamber
estimated depth of acces
- Distal from reference point to the roof of pulp chamber
- used to use burr against radiograph
- now its digital
- Do not explore with a bur
Length of 557 bur tip
4 mm