Tauraj Ehtizazi Flashcards

1
Q

What is Newtonian system?

A

Within a block of liquid the bottom layer is fixed, there is friction between the layers of the liquid. So when stress is applied the top layer will slide, and layers below will follow as there is friction present

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2
Q

What is shear rate?

A

Difference in velocity divided by the difference in height - s-1

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3
Q

What is shear stress?

A

Horizontal force applied per unit area - Nm-2

Pressure - vertical force

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4
Q

What is viscosity?

A

The ratio of shear stress to shear rate

Shear stress divided by shear rate

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5
Q

What are the units of viscosity?

A
Poise (P)
Or centipoise (cP) 
1cP = 0.01P
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6
Q

What is Newtonian fluid?

A

Viscosity depends on the temperature and not the shear rate or time
Viscosity does not change by prolonged or vigorous shaking (shear rate)
Linear graph which passes through the origin

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7
Q

What is a rheogram?

A

A plot of shear stress against shear rate for a liquid

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8
Q

What is pseudoplastic flow?

A

Fluid will flow as soon as shear stress is applied
Viscosity decreases by increasing shear rate (shaking)
Non-linear but passes through the origin

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9
Q

A low polymer concentration is which type of fluid?

A

Newtonian fluid

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10
Q

A high polymer concentration is which type of fluid?

A

Non-Newtonian fluid

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11
Q

What is dilatant flow?

A

Viscosity increases by increasing shear rate (shaking)

Non-linear but passes through the origin

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12
Q

How does dilatant flow occur?

A

At rest particles are closely packed and inter-particle voids are at a minimum which the vehicle can fill
But during flow the volume of solid material increases so now there is not enough fluid to fill the voids

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13
Q

What is Bingham or plastic flow?

A

Fluid will only flow once shear stress is above a threshold value
Viscosity usually stays constant
Linear but does not pass through the origin so there is a yield value

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14
Q

How can you determine the rheological properties of liquids?

A

Use a bob and cup viscometer

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15
Q

What is the usual speed of the bob in a bob and cup viscometer?

A

0.01-600 rpm

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16
Q

What does an upward curve mean in a rheogram?

A

Increasing shear rate increases shear stress

17
Q

What does a downward curve mean on a rheogram?

A

Decreasing shear rate decreases shear stress

18
Q

Upward and downward curves for non-Newtonian and pseudoplastic fluids are identical? True or False

A

False - Newtonian and pseudoplastic fluids have identical upward and downward curves

19
Q

Are the upward and downward curves on a thixotropic fluid identical?

A

No they are not identical

20
Q

What is thixotropic flow?

A

Viscosity depends on shear rate and its duration

The more shear rate applied over a prolonged time the less viscous the fluid

21
Q

What is the best fluid system to implement in a suspension?

A

Thixotropy - when bottle is shook viscosity is lowered
Disperses particles so uniform dose given
Particles maintained in suspended state so harder to sediment out

22
Q

What is the best system to implement in a parenteral formulation?

A

Thixotropy - fluid structure breaks down upon injection
consistency is recovered when in the muscle
sustained release
BUT NEVER DILUTE THE FLUID

23
Q

What is relative viscosity?

A

Ratio of viscosity of solution to viscosity of solvent

24
Q

What flow type has a Reynolds number below 2000?

A

Laminar

25
Q

What flow type has a Reynolds number above 4000?

A

Turbulent

26
Q

What flow type has a Reynolds number between 2000-4000

A

Transitional