Task 3 Flashcards

1
Q

What is childhood amnesia?

A

Phenomenon where adults are unable to remember specific events from the first few years of life

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2
Q

What are the characteristics of childhood amnesia?

A

Absence of declarative memory.

Childhood amnesia emerges by middle school (e.g. by 8-9 they have forgotten a substantial amount of early events)

Exponential forgetting in childhood

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3
Q

What are the two phases of childhood amnesia?

A

No remembrance of events in the first 2-3 years of life

Recall of few memories from ages 3-7 year.

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4
Q

Name the two main theories of childhood amnesia

A

Human cognitive/psychological theory

Biological theory

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5
Q

What are the two accounts for infantile amnesia according to the human cognitive theories?

A

Late emergence: The role of self, ToM, or language

Disappearance: Impairments in encoding, storage or recall

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6
Q

Name the two ways in which the biological theories account for infantile amnesia.

A

Immature brain development

Ongoing brain development/neurogenesis

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7
Q

One cognitive explanation for infantile amnesia is related to late emergence. Explain this perspective.

A

The ability to form enduring memories (offset infantile amnesia) in humans is related to the emergence of the acquisition of sense of self, ToM or language.

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8
Q

Another cognitive perspective in explaining infantile amnesia is that memories disappear. Explain this perspective.

A

Impairment in memory encoding, storage, or recall

Normal memory is never acquired by an infant, so this memory cannot be recalled during adulthood.

On the other hand, it may be that memory are formed in childhood & permanently stored, but its retrieval in adulthood is not possible

Memory retrieval deficit: memories are recalled when the retrieval conditions (both internal & external) closely match the retrieval conditions at encoding.

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9
Q

Explain the immature brain theory of infantile amnesia

A

either that infantile amnesia occurs because key structures for memory formation and storage are insufficiently mature at the time of memory formation to process these memories (“immature brain” theories).

Two key regions for declarative memory (cortex & hippocampus-dentate gyrus) show protracted postnatal development. Infantile amnesia may be due to the cortex not being online.

Older infants’ better encoding of information may be related to the more matured cortex.

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10
Q

According to the immature brain hypothesis of infantile amnesia, two key regions for declarative memory show protracted postnatal development.

What are these two regions?

A

Cortex & hippocampus dentate gyrus

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11
Q

Another theory of infantile amnesia is the ongoing brain maturation.. Explain.

A

alternatively, that the very process of ongoing maturation interferes with stable memory consolidation (“ongoing brain maturation” theories

The key idea here is that, while memory formation is more or less normal in infants, continued brain maturation after initial acquisition may interfere with stabilization or consolidation of the memory trace

continued postnatal production of new neurons in the hippocampus—regulates the ability to form enduring hippocampus-dependent memories.

The inability to form stable, persistent memories in early life coincides with a period of high neurogenesis, whereas the ability to form stable, persistent memories only emerges at later developmental periods as the rate of neurogenesis declines

integration of these “new neurons” degrades existing memories by either increasing the excitability (and therefore instability) of hippocampal memory networks or replacing synaptic connections in preexisting hippocampal memory circuits

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12
Q

Describe the complementary process account

A

The amnesia can be understood in terms of the complementary processes that improve memory traces and that degrade them.

There are processes (e.g. cog, mnemonic, neural) that contribute to the quality of memory traces & to the decreases in their vulnerability to forgetting.

Forgetting is at an exponential rate in childhood; it reduces the pools of memory formed into puddles, which makes them more difficult to retrieve.

Over the course of development, memories bear more and more features that are characteristic of autobiographical memory.

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13
Q

What is implicit memory?

A

unconscious learning that is expressed by changes in task performance as a result of experience

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14
Q

What is explicit memory (declarative)?

A

conscious recollection of facts and events.

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15
Q

Describe the development of non-spatial relational memory

A

nonspatial relational memory emerges between 6 and 12 months of age and

gradually becomes more sophisticated and flexible between 12 and 21 months of age;

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16
Q

Describe the development of basic spatial relational memory

A

in contrast, basic spatial relational memory emerges around 21 months of age and
subsequently becomes more elaborate after 42 months of age

17
Q

Episodic and semantic memory are thought to be independent during development.

How are semantic memories acquired?

A

through abstractions and multiple repetitions of episodic memories

18
Q

Give an example of how episodic memory can become semantic

A

A person encounters one episode of seeing a bed (episodic memory). Repeatedly seeing the same bed turns into semantic memory.

19
Q

Describe the perception and memory development

A

High-level stimuli (natural scenes & faces) memory grow from childhood through adolescence into young adulthood.

It is associated with the specialized cortical areas for faces and scenes (visual perception)

Scene-selective posterior parahippocampal gyrus (PHG) grows in size from childhood through adulthood, which correlates with improved recognition memory for scenes.

Developmental trends in perception (As noted above) influence episodic memory.

Attentional modulation of activation of perception is also important in the successful memory encoding.

20
Q

What is the difference between semantic memory in childhood and adulthood in relation to neural underpinnings?

A

During childhood, episodic encoding may depend more on perceptual system

Also, their semantic memory system may initially rely predominantly on MTL representations (especially perirphinal cortex)

In adulthood = established representations of semantic knowledge + top-down frontal control systems are most prominent.

21
Q

How does childhood amnesia relate to memory development?

A

Declarative memory development
The capacity to form and verbally recall declarative memories gradually emerges as an infant develops (from 24–36 mo of age)
Older children remember for longer than younger children

Perception to memory:
children rely more on perceptual processing in early childhood since semantic knowledge is less developed. Perceptual development may contribute to the improvement in semantic representations.

22
Q

Explain the hippocampus in relation to memory abilities

A

Hippocampus is connected to a wide range of neocortical & subcortical brain regions; their maturation also influence that of the hippocampus

Different relational memory abilities, all proposed here to be dependent on CA1 circuits at first and to

They become more flexible as CA3 and the dentate gyrus reach maturity,

These, however, emerging at different moments of postnatal development

23
Q

How is the hippocampus related to memory development?

A

Late maturation of dentate gyrus & putative functional circuits downstream from it might subserve the late emergence of certain types of hippocampus-dependent memory functions.

Layers receiving direct entorhinal projections exhibit earlier maturation than layers receiving projections via the dentate gyrus & the rest of the hippocampus-circuits; which means that they might subserve the earlier emergence of other types of hippocampus-dependent memory functions.

some hippocampal regions (CA2, the subiculum, presubiculum, and parasubiculum) seem to be relatively mature at birth; therefore they develop earlier than their main source of excitatory inputs, that is, the dentate gyrus, CA3, and

Interestingly, these four regions are characterized by their particularly significant connections with different subcortical regions.

These data suggest that hippocampal-subcortical circuits involving these four regions might mature the earliest, at birth or shortly after, and subserve the emergence of the earliest ‘‘hippocampus-dependent’’ memory functions.

24
Q

When does recognition memory develop?

A

present from birth

25
Q

What are the neural correlates of recogntiion memory?

A

evidence suggest that at least part of the hippocampal formation circuitry is relatively mature at birth and might subserve the early emergence of recognition memory around birth

26
Q

When does basic relational memory (spatial and non-spatial) develop?

A

9 and 25 months

27
Q

What are the neural underpinnings of basic relational memory?

A

Subserved by the maturation of the CA1 – place cells. Context dependent & inflexible

28
Q

When do complex relational memory develop?

A

21 months

29
Q

What are the neural underpinnings of complex relational memory functions?

A

Reflection of maturation of CA3 & dentate gyrus regions & related circuits.

30
Q

When does episodic memory develop?

A

4 years

31
Q

What are the neural underpinnings of episodic memmory?

A

maturation of dentate gyrus

32
Q

What is the function of the hippocampus in relation to memory?

A

Allows for integration, separation, and comparison of info from distributed brain regions
Learns rapidly using separated representations to encode details of specific events.

33
Q

What is the function of the neocortex in relation to memory?

A

Has a slow learning rate & uses overlapping distributed representations to extract general statistical structure of environment

34
Q

What is the role of the mPFC in relation to memory?

A

Integrates abstract representations across modalities with behavioural output
Detects congruency of new info with existing info in neocortex

35
Q

What is the role of the LPFC in relation to memory?

A

Goal-directed control functions to support encoding of discrete memory traces
And subsequent strategic retrieval & evaluation of stored representations

36
Q

What is the role of the medial temporal lobe in relation to memory?

A

Binds elements of new information into a representation when there is low congruency between new and existing info.

37
Q

Describe the PIMMS model

A

Has 3 memory systems: perceptual, semantic, and episodic.

Predictive memory for item categories are based on the interactions between the hippocampus, periphinal cortex, and ventral visual system.

Predictive memory is related to higher conceptual abstract knowledge that arise a result of consistensies across diverse experiences.

38
Q

Describe the PIMMS model in relation to its neural systems and functions

A

Contents (i.e. features, objects & contexts) are represented in different layers, each corresponding to the SPI memory system.

Retrieval from perceptual memory (occipital temporal cortex – OTC)  priming

Retrieval from semantic (Perirphinal cortex & anterior temporal lobe)  familiarity

Retrieval from episodic (hippocampus)  recollection
Recognition memory = semantic & episodid memory.