Targets For Drug Interactions Flashcards
Lock and key mechanism targets…
Cell membrane, nucleus or cytoplasm
Drugs bind to target tissue to produce a….
Response
Some drugs target ion channels causing them to…
Open or close.
Insulin targets…
Carrier molecules on cell membranes.
Some drugs alter the final result when they bind to….
Enzymes or DNA
Other drug targets include…
- Bacteria
- Viruses
- Fungi
- Amoeba
- Parasites, eg, worms.
Aspirin and Viagra bind to…
Enzymes.
Salbutamol and beta-blockers bind to…
Receptors.
Local anaesthetics and benzodiazepines bind to…
Channels on cell membranes.
Omeprazole and cocaine bind to…
Carrier molecules.
Steroids bind to…
DNA.
Penicillin and other antibiotics bind to…
Foreign proteins.
What binds to a receptor causing a response to occur?
An agonist.
What does an agonist sometimes do?
Mimic chemicals found in the body, eg, salbutamol mimics adrenalin in an asthma attack.
What binds to a receptor to stop other chemicals from producing a response?
An antagonist.
An example of an antagonist is…
A beta-blocker.
How long does an antagonist last?
A long time, maybe even forever.
Correct order of a response being triggered…
Drug binds to receptor—-> Activation of 2nd messenger—-> Cascade of enzyme reactions—-> RESPONSE OCCURS.
Nuclear receptors….
Lipid soluble steroids dissolve in nuclear membrane.
Cellular response to drugs….
Contraction?
Muscle cells.
Cellular response to drugs….
Secretion?
Glands.
Cellular response to drugs….
Excitation?
Nerve cells/ muscle cells.
Cellular response to drugs….
Inhibition?
Nerve cells.
Cellular response to drugs….
Interruption of cell cycle?
Tumour cells.
What is potency?
How much of a drug is needed to produce a certain response in a certain person.
If a drug has a high potency…
Only a small dose is required to produce a response.
A smaller dose is…
- Cheaper
- Easier to administer
- Will have less side effects for patient.
On a dose-response curve a bigger dose will cause a…
Bigger response.
