Targeted Therapy

Question 1

Target validation process

Answer 1

causal relation b/w target and disease
has to do with:
1. specificity
2. affinity
3. mode of action (short term vs long term)
4. regulation of effects

Question 2

dose-effect relationship

Answer 2

quantitative

at individual level

Question 3

dose-response relationship

Answer 3

quantitative
at group level (how many pts responded in a group?)
most drugs use this

Question 4

Biomarkers for selection in cancer therapy= EGFR

Answer 4

Erlotinib (lung cancer)

Cetuximab (colon cancer)

Question 5

MammaPrint

Answer 5

validated for breast cancer pts
predict risk of distant metastasis
aggressive tx can be considered in pts with poor prognosis

Question 6

DPD (dihydroprimidine dehydrogenase)

Answer 6

enzyme that breaks down 5-FU

aberrant methylation of DPYD promoter causes DPD deficiency

Question 7

Thymidylate synthase (TS)

Answer 7

target for 5-FU

overexpression is linked to drug resistance