PD II

Question 1

SOCS Trial

Answer 1

measured mild asthma with salmeterol

Arg pts did worse with drug than Gly pts

Question 2

SLIC trial

Answer 2

measured more moderate asthma with salmeterol

Arg pts did worse with drug than Gly pts

Question 3

Impact of beta-receptor polymorphisms

Answer 3

Arg16= assoc w/ adverse outcomes with regular use of SABAs

Arg16 does not appear to affect adverse outcomes w/ LABAs WHEN USED WITH ICS

Question 4

ADULT and CAMP study

Answer 4

studied CRHR1 polymorphism
ADULT= adults
CAMP= in kids
pts with the polymorphism did much better with corticosteroids than the heterozygous or wild type (mutation increases efficacy)

Question 5

Genome Wide Association Studies (GWAS)

Answer 5

sequence entire genome of each case subject and compare each and look at every SNP that is diff b/w case cohort and control cohort

Question 6

GLCCI1

Answer 6

Glucocorticoid Induced Transcript 1
expressed in lung and immune cells
glucocorticoid therapy increases expression
16% of pop has mutation (mutation results in decreased expression and thus decreased efficacy of glucocorticoids)